Results 31 to 40 of about 412,242 (204)

Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery

Pharmaceutics, 2021
Bowl-shaped biodegradable polymersomes, or stomatocytes, have much potential as drug delivery systems, due to their intriguing properties, such as controllable size, programmable morphology, and versatile cargo encapsulation capability.
Jingxin Shao, Shoupeng Cao, Hanglong Wu, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest   +4 more
doaj   +1 more source

Stereochemistry of Complex Marine Natural Products by Quantum Mechanical Calculations of NMR Chemical Shifts: Solvent and Conformational Effects on Okadaic Acid

Marine Drugs, 2014
Marine organisms are an increasingly important source of novel metabolites, some of which have already inspired or become new drugs. In addition, many of these molecules show a high degree of novelty from a structural and/or pharmacological point of view.
Humberto J. Domínguez, Guillermo D. Crespín, Adrián J. Santiago-Benítez, José A. Gavín, Manuel Norte, José J. Fernández, Antonio Hernández Daranas   +6 more
doaj   +1 more source

Lipid A analog CRX-527 conjugated to synthetic peptides enhances vaccination efficacy and tumor control

npj Vaccines, 2022
Adjuvants play a determinant role in cancer vaccination by optimally activating APCs and shaping the T cell response. Bacterial-derived lipid A is one of the most potent immune-stimulators known, and is recognized via Toll-like receptor 4 (TLR4). In this
Elena Tondini, Niels R. M. Reintjens, Giulia Castello, Tsolere Arakelian, Marjolein Isendoorn, Marcel Camps, Jana Vree, Gijs A. van der Marel, Dmitri V. Filippov, Jeroen D. C. Codee, Ferry Ossendorp   +10 more
doaj   +1 more source

Inherently Fluorescent Peanut-Shaped Polymersomes for Active Cargo Transportation

Pharmaceutics, 2023
Nanomotors have been extensively explored for various applications in nanomedicine, especially in cargo transportation. Motile properties enable them to deliver pharmaceutical ingredients more efficiently to the targeted site. However, it still remains a
Jianhong Wang, Yingtong Luo, Hanglong Wu, Shoupeng Cao, Loai K. E. A. Abdelmohsen, Jingxin Shao, Jan C. M. van Hest   +6 more
doaj   +1 more source

Iron biogeochemistry across marine systems progress from the past decade [PDF]

, 2010
Based on an international workshop (Gothenburg, 14–16 May 2008), this review article aims to combine interdisciplinary knowledge from coastal and open ocean research on iron biogeochemistry. The major scientific findings of the past decade are structured
Achterberg, E. P., Ardelan, M. V., Baker, A. R., Breitbarth, E., Bucciarelli, E., Chever, F., Croot, P. L., Duggen, S., Gledhill, M., Hassellöv, M., Hassler, C., Hoffmann, L. J., Hunter, K. A., Hutchins, D. A., Ingri, J., Jickells, T., Lohan, M. C., Nielsdό, Sarthou, G., Schoemann, V., Trapp, J. M., Turner, D. R., Ye, Ying   +22 more
core   +5 more sources

Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors

Molecules, 2022
The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction ...
Amarender Manchoju, Renaud Zelli, Gang Wang, Carla Eymard, Adrian Oo, Mona Nemer, Michel Prévost, Baek Kim, Yvan Guindon   +8 more
doaj   +1 more source

An investigation on the skewness patterns and fractal nature of research productivity distributions at field and discipline level

, 2017
The paper provides an empirical examination of how research productivity distributions differ across scientific fields and disciplines. Productivity is measured using the FSS indicator, which embeds both quantity and impact of output.
Abramo, Giovanni, D'Angelo, Ciriaco Andrea, Soldatenkova, Anastasiia   +2 more
core   +1 more source

BIO-ORGANIC CHEMISTRY QUARTERLY REPORT. March through05/1963 [PDF]

, 1963
This report covers the following titles: (1) Fertility and litter size of normally ovulated and artificially ovulated mice; (2) Further studies on sterility produced in male mice by deuterium oxide; (3) Planarian disaggregation; (4) Uptake of organic compounds by planarians.
openaire   +4 more sources

BIO-ORGANIC CHEMISTRY QUARTERLY REPORT. June through August1963 [PDF]

, 1963
This report covers the following titles: (1) The Effects of 8-Methyl Lipoic Acid on the Evolution of Oxygen and Reduction of Carbon Dioxide during Photosynthesis; (2) Further {sup 14}C and {sup 15}N Tracer Studies of Amino Acid Synthesis during Photosynthesis by Chlorella Pyrenoidosa; (3) Two-Dimensional High Voltage, Low-Temperature Paper ...
openaire   +5 more sources

Enantioselective construction of ortho-sulfur- or nitrogen-substituted axially chiral biaryls and asymmetric synthesis of isoplagiochin D

Nature Communications, 2022
Ortho-heteroatom-substituted axially chiral biaryls are valuable structures in synthetic and medicinal chemistry. Here, the authors established an efficient synthesis of these chiral structures via asymmetric cross-coupling.
He Yang, Wenjun Tang
doaj   +1 more source