Results 91 to 100 of about 661,511 (263)
¿Es viable la ISO 14000 para el contexto colombiano?: una aproximación a partir de análisis de casos [PDF]
, 2006 The present document presents the final results of the investigation of a research that in their development integrated three methodologies of investigation, interpretive analysis of sources on organization and business in light of the concept of ...
Ariza Buenaventura, Danilo +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Gayana: Botanica, 2009 Alstroemeria L. (Alstroemenaceae) es un género de monocotiledoneas americano, con dos centros de distribución en el continente: Brasil y Chile. En Chile está representado por alrededor de 33 especies, la gran mayoría de ellas distribuidas en la zona ...
Daniel Cajas +3 more
doaj
Evaluación del desarrollo psicomotor, mediante el test de aprendizaje y desarrollo infantil Tadi, en niños desde 3 meses hasta 6 años, pertenecientes a una comunidad pehuenche situada en Alto Bío Bío, un estudio exploratorio piloto [PDF]
, 2018 Tesis (Magíster en Neurorehabilitación)El desarrollo psicomotor (DSM) se refiere al conjunto de habilidades físicas, cognitivas, lingüisticas, socioafectivas y temperamentales; que el niño va adquiriendo producto de la maduración del sistema nervioso ...
Miranda Sandoval, Nancy Edith
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Efecto colateral. Fragmentos de un paisaje agredido
Arquitecturas del Sur, 2008 Los sistemas ecológicos son extremadamente sensibles a la intervención del hombre, fundamentalmente porque posee la capacidad de controlar, reflexionar y modificar la cultura.
Jorge Pasmiño
doaj
Realizar una ficha técnica para la elaboración de una propuesta de una guía titulada: Recomendaciones técnicas para el manejo adecuado de la especie Hyloscirtus masphi n. sp. dentro de la reserva privada de Mashpi Pichincha-Ecuador [PDF]
, 2018 Se ha reportado una reducción de las poblaciones de anfibios a nivel mundial, y, una de las principales causas de su disminución, es por la aparición del hongo Batrachochytrium dendrobatidis, causante de la enfermedad llama Chytridiomycosis ...
Hernández Bravo, Jonathan Joao +1 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source