Results 81 to 90 of about 661,511 (263)

A VEGETATION MAP OF NEVADOS DE CHILLAN VOLCANIC COMPLEX, BIO-BIO REGION, CHILE CARTOGRAFIA DE VEGETACION DEL COMPLEJO VOLCANICO NEVADOS DE CHILLAN, REGION DEL BIO-BIO, CHILE

Gayana: Botanica, 2008
A vegetation survey of the AndeanNevados de Chillan volcanic complex, Bio-Bio Region, Chile, resulted in the preparation of a colour vegetation map, based on photo-interpretation of an aerial photograph of 1998.
Simon Pfanzelt, Jürke Grau, Roberto Rodríguez   +2 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Pensar Históricamente desde un Presente Controvertido: Causas y Consecuencias del Conflicto Hispano-Mapuche según el Estudiantado

Historia Social y de la Educación
En esta investigación nos proponemos dos objetivos: por un lado, analizar el dominio que los estudiantes de enseñanza básica y media de la región del Bio Bio (Chile) tienen de las causas y consecuencias del conflicto hispano-mapuche (S. XVI y S.XVII); y,
Carlos Muñoz-Labraña, Rosendo Martínez-Rodríguez, Sixtina Pinochet-Pinochet   +2 more
doaj   +3 more sources

Ordenamiento territorial de la zona costera, una demanda del desarrollo regional

Urbano, 2001
Zona Costera de la Región del Bío-Bío, desde Cobquecura hasta Tirúa.
Néstor Zapata Retamal
doaj  

Hacia un modelo de desarrollo incluyente para el Valle del Cauca [PDF]

Este artículo se enfoca en la identificaciónde aquellos factores estructuralesque explican la pérdida dedinamismo económico de largo plazoen Colombia y, en particular, en elValle del Cauca.
CARLOS HUMBERTO ORTIZ, JOSÉ IGNACIO URIBE   +1 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Transporte intermodal, competitividad sistémica y puertos en la Región del Bío-Bío

Urbano, 2000
• Algunos cambios en la economía mundial. • Nuevos conceptos de competitividad. • Transporte multimodal y nuevo paradigma.
Luis Fernando Méndez Briones
doaj  

Cambiar el modelo urbano [PDF]

, 2017
During the present century, which started more than a decade ago, urban planning is executed in accordance with several requirements, determinants and objectives that have nothing to do with the needs of citizens.
Fariña Tojo, José
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source