Results 51 to 60 of about 661,511 (263)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Libro de resumenes [PDF]

, 2015
It is a pleasure for the editorial committee and scientific committee to present the memoirs and book of summaries of our II Colombian Congress and III Latin American Congress of Mastozoology, held in the city of Bogotá, Colombia, in the facilities of ...
González-Maya, José F., Jiménez-Alvarado, Sebastián, Marín-Carvajal, Lorena   +2 more
core   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Repensando el turismo sustentable [PDF]

, 2017
El libro aborda la problemática del turismo sustentable que, por un lado, al compartir contornos nebulosos con la sustentabilidad, funciona como un nuevo circuito de acumulación fundamentado en un discurso retórico de desarrollo local; por el otro, se ...
Alimonda, Héctor, Alimonda, Héctor , Calistro Fortes, Simone, Calistro Fortes, Simone , Cañada, Ernest, Cañada, Ernest , CHAVEZ DAGOSTINO, ROSA MARIA, CHAVEZ DAGOSTINO, ROSA MARIA, Fuller Osores, Norma, Fuller Osores, Norma , GONZALEZ DAMIAN, ALFONSO, GONZALEZ DAMIAN, ALFONSO, GONZALEZ LUNA, LIRIO AZAHALIA, GONZALEZ LUNA, LIRIO AZAHALIA, GUTIERREZ VALDES, NOEMI, GUTIERREZ VALDES, NOEMI, HERNANDEZ LARA, OLIVER GABRIEL, HERNANDEZ LARA, OLIVER GABRIEL, MALDONADO IBARRA, OSCAR ALBERTO, MALDONADO IBARRA, OSCAR ALBERTO, MEJIA ROCHA, MONICA ISABEL, MEJIA ROCHA, MONICA ISABEL, MIRANDA ZAMBRANO, GLORIA AMPARO, MIRANDA ZAMBRANO, GLORIA AMPARO, MONTERROSO SALVATIERRA, NEPTALI, MONTERROSO SALVATIERRA, NEPTALI, NAVARRO TRUJILLO, MINA LORENA, NAVARRO TRUJILLO, MINA LORENA, PALAFOX MUÑOZ, ALEJANDRO, PALAFOX MUÑOZ, ALEJANDRO, Pereira, Roberto, Pereira, Roberto, ROJAS CALDELAS, ROSA IMELDA, ROJAS CALDELAS, ROSA IMELDA, Roma Montecino, María Florencia, Roma Montecino, María Florencia , Romero Aravena, Hugo, Romero Aravena, Hugo , Rosati, Facundo Luis, Rosati, Facundo Luis, VAZQUEZ TORIZ, ROSALIA, VAZQUEZ TORIZ, ROSALIA, Zizumbo Villareal, Lilia, Zizumbo Villareal, Lilia   +43 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A computational study of mechanical properties of collagen-based bio-composites

International Biomechanics, 2020
Studying changes in collagen deformation behavior at the nanoscale due to variations in mineralization and hydration is important for characterizing and developing collagen-based bio-composites.
Marco Fielder, Arun K. Nair
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Registro del patrimonio arqueológico de los Pukaras en el área arqueológica del Monte Puñay, provincias de Cañar y Chimborazo. [PDF]

, 2019
El propósito de la investigación es registrar del patrimonio arqueológico de los Pukaras en el área arqueológica del Monte Puñay provincia de Cañar y Chimborazo; donde se efectuó el siguiente procedimiento: se utilizó técnicas de investigación ...
Peralta Arias, Walter Jeovanny
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source