Results 41 to 50 of about 557,097 (227)

GDPPH1 induces cell cycle arrest by downregulation of CDK4/Cyclin D1 via the m6A-METTL14-YTHDF2 axis, attenuating glioblastoma progression

Cell Death and Disease
Glioblastoma (GBM) is the most prevalent and aggressive primary brain tumor in adults, with current therapies failing to achieve significant clinical advancements.
Sijia Li, Ruijie Yuan, Jinxuan Su, Ruxi Chen, Xinyi Qu, Lele Zhao, Xiaofeng Zhou, Qiuming Zou, Zhijing Zhang, Siyu Yang, Jianqin Lai, Xiaosong Zhuang, Zisheng Li, Kai Cui, Shengwei Hu, Yongqi Liu, Lili Liu, Zepeng Luo, Zhongping Luo, Wen Li, Yu Yan, Yubo Zhang, Zhiming Zheng, Qi Qi   +23 more
doaj   +1 more source

Molecular mechanisms, crosstalk and therapeutic potential of novel acylation modifications in cardiovascular and cerebrovascular diseases

Acta Pharmaceutica Sinica B
Metabolic reprogramming, the fundamental process by which cells adapt to fluctuations in energy demands, is pivotal in the pathophysiology of cardiovascular and cerebrovascular diseases (CCVDs).
Wanchun Li, Weile Ye, Jiaojiao Wang, Zhiping Liu   +3 more
doaj   +1 more source

Bioactive Chemical Constituents and Pharmacological Activities of Ponciri Fructus

Molecules, 2022
Ponciri Fructus is a crude drug obtained from the dried immature fruits of Poncirus trifoliata (L). Raf. (Syn. Citrus trifoliata L.). This study aims to compile and analyze the ethnomedicinal uses, bioactive constituents, and pharmacological activities ...
Gopal Lamichhane, Jitendra Pandey, Hari Prasad Devkota   +2 more
doaj   +1 more source

Bioinspired Co‐Assembly Enables Multiscale Architected Hydrogels for 3D Printing With Integrated Antibacterial and Bioactive Functions

Advanced Functional Materials, EarlyView.
A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov, Francesca Netti, Sigal Rencus‐Lazar, Moran Aviv, Lihi Adler‐Abramovich   +4 more
wiley   +1 more source

Bioactive constituents from Euphorbia quinquecostata and Mezoneuron cucullatum.

, 1996
Bioactive constituents from Euphorbia quinquecostata and Mezoneuron ...
Zakaria Heriel. Mbwambo (7957445)
core   +2 more sources

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells

Acta Pharmaceutica Sinica B
Abdominal aortic aneurysm (AAA) is a deadly condition of the aorta, carrying a significant risk of death upon rupture. Currently, there is a dearth of efficacious pharmaceutical interventions to impede the advancement of AAA and avert it from rupturing ...
Weile Ye, Pinglian Yang, Mei Jin, Jiami Zou, Zhihua Zheng, Yuanyuan Li, Dongmei Zhang, Wencai Ye, Zunnan Huang, Jiaojiao Wang, Zhiping Liu   +10 more
doaj   +1 more source

Biodegradable 3D‐Printable and Coatable Antifouling Composites for Marine Applications

Advanced Functional Materials, EarlyView.
Marine biofouling damages submerged surfaces and raises greenhouse gas emissions. Biodegradable antifouling biocomposites were developed by hot‐mixing beeswax, Tween 80, and calcium stearate or stearic acid. Adjusting the component ratio enables processing via hot‐pressing, 3D‐printing, or dip‐coating.
Gabriele Corigliano, Lorenzo Ravelli, Martina Nardi, Ruowen Tu, Elena Bellini, Valerio Isa, Carlo Filippeschi, Roberta Finazzi, Luca Ceseracciu, Niloofar Paknezhad, Vincenzo Scribano, Paolo Galli, Silvia Lavorano, Simone Montano, Barbara Mazzolai, Marco Contardi, Pietro Cataldi, Athanassia Athanassiou   +17 more
wiley   +1 more source

Research Progress of Cholestatic Liver Disease-Related Pruritus in Chinese Medicine and Western Medicine

Chinese Medicine and Natural Products
Pruritus is common in cholestatic liver disease, with a high clinical incidence rate and complex pathogenesis. Accumulation of potential pruritus inducers such as steroids, bile acids, and lysophosphatidic acid in the systemic circulation is the main ...
Wenzhang Dai, Hong Nie
doaj   +1 more source

Additively Manufactured Geometry‐Reconfigurable Soft Neural Probes With Monolithic Multifunctionality

Advanced Functional Materials, EarlyView.
A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee, Xinyi Wang, Sirui Li, Jihyang Park, Hyunseok Lee, Jianting Yao, Kedar Narayan, Yuqi Wang, Jiashu Ren, Yueqi Deng, Salahuddin Ahmed, Denver I. Greenawalt, Archana Pandiyan, Loganathan Veeramuthu, Chi‐Ching Kuo, Tao Zhou   +15 more
wiley   +1 more source