Results 91 to 100 of about 1,302,906 (282)

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Design, synthesis, and evaluation of 1,4-benzothiazine-3-one containing bisamide derivatives as dual inhibitors of Staphylococcus aureus with plausible application in a urinary catheter

Frontiers in Chemistry
In this study, 1,4-benzothiazine-based bisamide derivatives, a new class of antibacterial agents targeting bacterial peptide deformylase (PDF), were designed and synthesized to combat Staphylococcus aureus infection.
Kaushal Naithani, Arka Das, Mamta Ushare, Subham Nath, Subham Nath, Rashmita Biswas, Rashmita Biswas, Anirban Kundu, Kazi Tawsif Ahmed, Utpal Mohan, Utpal Mohan, Subhendu Bhowmik   +11 more
doaj   +1 more source

Historeceptomic fingerprints for drug-like compounds

Frontiers in Physiology, 2015
Most drugs exert their beneficial and adverse effects through their combined action on several different molecular targets (polypharmacology). The true molecular fingerprint of the direct action of a drug has two components: the ensemble of all the ...
Evgeny eShmelkov, Arsen eGrigoryan, James eSwetnam, Junyang eXin, Doreen eTivon, Sergey eShmelkov, Sergey eShmelkov, Timothy eCardozo   +7 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

10C fitness-scores

, 2016
Gene deletions identified by ECK number.
Krogan, Nevan, Osadnik, Hendrik, Carol A. Gross (498580), Shiver, Anthony L., Bo Li (112195), Anthony L. Shiver (238214), Li, Bo, Gross, Carol A., George Kritikos (505206), Kritikos, George, Hendrik Osadnik (3162075), Typas, Athanasios, Nevan Krogan (7571), Athanasios Typas (505208)   +13 more
core   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Bioactivity in silica/poly(γ-glutamic acid) sol–gel hybrids through calcium chelation [PDF]

, 2013
Bioactive glasses and inorganic/organic hybrids have great potential as biomedical implant materials. Sol–gel hybrids with interpenetrating networks of silica and biodegradable polymers can combine the bioactive properties of a glass with the toughness ...
Romer, Frederik, Jones, Julian R., Wang, Daming, McPhail, David S., Smith, Mark E., Valliant, Esther M., Hanna, John V.   +6 more
core   +1 more source

Application of generative adversarial networks (GAN) and reinforcement learning in drug classification

Discover Computing
MolGAN is a generative adversarial network (GAN) model specially designed for molecular graph structures. It uses a graph convolutional network (GCN) as the discriminator and combines a reinforcement learning mechanism to optimize the generator.
Ling Qiu, Jingnian He, Xiongbo Huang
doaj   +1 more source

Combination of Gemcitabine with Cell-Penetrating Peptides: A Pharmacokinetic Approach Using In Silico Tools

Biomolecules, 2019
Gemcitabine is an anticancer drug used to treat a wide range of solid tumors and is a first line treatment for pancreatic cancer. Our group has previously developed novel conjugates of gemcitabine with cell-penetrating peptides (CPP), and here we report
Abigail Ferreira, Rui Lapa, Nuno Vale
doaj   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source