c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cβ) gene [PDF]
Oncogene, 2002 The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in the control of cell growth and differentiation and broadly implicated in tumorigenesis. Understanding the function of c-MYC and its role in cancer depends upon the identification of c-MYC target genes. Here we show that c-MYC induces the activity of Protein Kinase A (PKA), a
Michela Mattioli +2 more
exaly +3 more sources
Targeting Catecholamines to Develop New Drugs for Attention Deficit Hyperactivity Disorder [PDF]
Journal of Medicine and Life Science, 2021 The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors.
Sung-Cherl Jung +5 more
doaj +1 more source
Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography [PDF]
Acta Poloniae Pharmaceutica, 2023 Phenothiazine and its derivatives exhibit many properties. Hence they are the starting structures for many new potential drugs, biologically active compounds, dyes, etc.
Sobczak Agnieszka +3 more
doaj +1 more source
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
Biology Open, 2021 Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear.
Wanxu Guo +4 more
doaj +1 more source
Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2020 A theoretical approach to the pKA assessment for dimers of saturated carboxylic acids CnH2n+1COOH( n = 6 - 16) and amines CnH2n+1NH2 (n = 6 — 16) at the air/water interface is proposed.
Yu.B. Vysotsky, E.S. Kartashynska
doaj +1 more source
The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro
Platelets, 2022 In the clinic, the supply of platelets is frequently insufficient to meet transfusion needs. To address this issue, many scientists have established the derivation of functional platelets from CD34+ cells or human pluripotent stem cells (PSCs).
Weihua Huang +11 more
doaj +1 more source
Microorganisms, 2020 Efficient utilization of both glucose and xylose from lignocellulosic biomass would be economically beneficial for biofuel production. Recombinant Saccharomyces cerevisiae strains with essential genes and metabolic networks for xylose metabolism can ...
Meiling Wu +8 more
doaj +1 more source
PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice [PDF]
Communications Biology, 2021 AbstractTemporal lobe epilepsy (TLE) is one of the most common and intractable neurological disorders in adults. Dysfunctional PKA signaling is causally linked to the TLE. However, the mechanism underlying PKA involves in epileptogenesis is still poorly understood.
Jingliang Zhang +7 more
openaire +3 more sources
PKA preperation of some diimines acids derived from benzil [PDF]
مجلة التربية والعلم, 2005 The study is concerned with the preparation of four acids having diimines in a forms of Schiff bases as well as oxime in the same molecule. The acids prepared are identified by using UV, IR, NMR and melting points.
Khaleel Al-Nuami +2 more
doaj +1 more source
Effect of Atomic Charge and Some Physical Properties on pKa of Substituted Pyridines [PDF]
مجلة التربية والعلم, 1970 A number of different levels of theoretical calculations have been used for assigning the Mulliken charge to the atoms of mono-substituted pyridines, including both quantum chemical and empirical schemes.
Mahmmoud S. Saieed, Zaheda A. Najim
doaj +1 more source