Results 11 to 20 of about 191,349 (283)
Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction. [PDF]
PLoS BiologyHedgehog (HH) signaling in vertebrates is dependent on the primary cilium, an organelle that scaffolds signal transduction. HH signals induce ciliary enrichment of Smoothened (SMO) and ciliary departure of the G protein-coupled receptor (GPCR) GPR161 to ...
Thi D Nguyen +4 more
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Targeting Catecholamines to Develop New Drugs for Attention Deficit Hyperactivity Disorder [PDF]
Journal of Medicine and Life Science, 2021 The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors.
Sung-Cherl Jung +5 more
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Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography [PDF]
Acta Poloniae Pharmaceutica, 2023 Phenothiazine and its derivatives exhibit many properties. Hence they are the starting structures for many new potential drugs, biologically active compounds, dyes, etc.
Sobczak Agnieszka +3 more
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High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
Biology Open, 2021 Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear.
Wanxu Guo +4 more
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Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2020 A theoretical approach to the pKA assessment for dimers of saturated carboxylic acids CnH2n+1COOH( n = 6 - 16) and amines CnH2n+1NH2 (n = 6 — 16) at the air/water interface is proposed.
Yu.B. Vysotsky, E.S. Kartashynska
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The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro
Platelets, 2022 In the clinic, the supply of platelets is frequently insufficient to meet transfusion needs. To address this issue, many scientists have established the derivation of functional platelets from CD34+ cells or human pluripotent stem cells (PSCs).
Weihua Huang +11 more
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Microorganisms, 2020 Efficient utilization of both glucose and xylose from lignocellulosic biomass would be economically beneficial for biofuel production. Recombinant Saccharomyces cerevisiae strains with essential genes and metabolic networks for xylose metabolism can ...
Meiling Wu +8 more
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PKA preperation of some diimines acids derived from benzil [PDF]
مجلة التربية والعلم, 2005 The study is concerned with the preparation of four acids having diimines in a forms of Schiff bases as well as oxime in the same molecule. The acids prepared are identified by using UV, IR, NMR and melting points.
Khaleel Al-Nuami +2 more
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Effect of Atomic Charge and Some Physical Properties on pKa of Substituted Pyridines [PDF]
مجلة التربية والعلم, 1970 A number of different levels of theoretical calculations have been used for assigning the Mulliken charge to the atoms of mono-substituted pyridines, including both quantum chemical and empirical schemes.
Mahmmoud S. Saieed, Zaheda A. Najim
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Benchmarking pKa prediction [PDF]
, 2006 Background: pKa values are a measure of the protonation of ionizable groups in proteins. Ionizable groups are involved in intra-protein, protein-solvent and protein-ligand interactions as well as solubility, protein folding and catalytic activity.
Davies, M.N. +11 more
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