Results 11 to 20 of about 147,183 (245)

Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP

Cells, 2020
Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).
Alessandro Dema, Dörte Faust, Katina Lazarow, Marc Wippich, Martin Neuenschwander, Kerstin Zühlke, Andrea Geelhaar, Tamara Pallien, Eileen Hallscheidt, Jenny Eichhorst, Burkhard Wiesner, Hana Černecká, Oliver Popp, Philipp Mertins, Gunnar Dittmar, Jens Peter von Kries, Enno Klussmann   +16 more
doaj   +1 more source

Neuromodulation of excitatory synaptogenesis in striatal development

eLife, 2015
Dopamine is released in the striatum during development and impacts the activity of Protein Kinase A (PKA) in striatal spiny projection neurons (SPNs).
Yevgenia Kozorovitskiy, Rui Peixoto, Wengang Wang, Arpiar Saunders, Bernardo L Sabatini   +4 more
doaj   +1 more source

pKa Determination of Strongly Acidic C-H Acids Bearing a (Perfluoroalkyl)sulfonyl Group in Acetonitrile by Means of Voltammetric Reduction of Quinone

Electrochemistry, 2021
A voltammetric method has been developed for the determination of the acid dissociation constant (pKa) of (RfSO2)2CHR (Rf = perfluoroalkyl), which is a strongly acidic molecule that serves as an acid catalyst.
Akira KOTANI, Hikaru YANAI, Takashi MATSUMOTO, Hideki HAKAMATA   +3 more
doaj   +1 more source

Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK

Adipocyte, 2020
The prevalence of obesity and its comorbidities has sparked a worldwide concern to address rates of adipose tissue accrual. Recent studies have demonstrated a novel role of Zyflamend, a blend of natural herbal extracts, in regulating lipid metabolism in ...
Dexter Puckett, Mohammed Alquraishi, Dina S. Alani, Samah Chahed, Victoria D. Frankel, Dallas Donohoe, Brynn Voy, Jay Whelan, Ahmed Bettaieb   +8 more
doaj   +1 more source

Synthesis of sulfacetamide and pKa calculation of its derivatives using ab initio methods [PDF]

شیمی کاربردی روز, 2018
Sulfonamides are a class of pharmaceutical compounds included –SO2NH– group that show a variety of biological activities. Sulfacetamide is an N-acyl sulfonamide that has broad-spectrum antibiotic effects.
Mohammad Reza Noorbala, Mansoor Namazian, Fatemah Tamaddon, Hamide Ajamein Ajamein   +3 more
doaj   +1 more source

Estimation of pKa, Analgesic, CNS Depressant Activities of Imidazolinone Derivatives By Correlation With Theoretical Parameters Based on Quantum Chemical Method [PDF]

مجلة التربية والعلم, 2018
Regression analysis is used for the estimation of the pKa values, %analgesic activity (%AA) and % decreasing activity of central nervous system (CNS) depressant property (%DA) of eight substituted imidazolin-5(4H)-ones by using various types of ...
Emad A. S. Al-Hyali
doaj   +1 more source

Potentiometric investigation of acid-base equilibria of two new pyrimidine derivatives in various methanol-water media [PDF]

Journal of the Serbian Chemical Society, 2006
The acid-base properties of 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-one (L1) and 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-thione (L2) were investigated potentiometrically at an ionic strength of 0.10M(LiCl) in 19.8, 33.6 and 55.9 % (v/v) methanol ...
Kiliç Hasan, Birol Er
doaj   +1 more source

Effect of warmed ropivacaine solution on onset and duration of axillary block [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundBicarbonate, as an adjunct increasing the non-ionized form of local anesthetics, can reduce latency and prolong duration of regional nerve block.
Rippy Lee, Young Mi Kim, Eun Mi Choi, Young Ryong Choi, Mi Hwa Chung   +4 more
doaj   +1 more source

Molecular pKa Prediction with Deep Learning and Chemical Fingerprints

Cumhuriyet Science Journal
Today, drug discovery and design, the determination of molecular properties, in particular the determination of a molecule's pKa value, is essential for understanding and optimising the biological activity of drugs.
Fatih Mehmet Avcu
doaj   +1 more source

The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways

Journal of Inflammation Research, 2021
Xinwei Cao,1 Yajun Li,1 Jianrong Shi,2 Huifang Tang1 1Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Clinical Laboratory, Children’s Hospital ...
Cao X, Li Y, Shi J, Tang H
doaj