Results 11 to 20 of about 194,517 (249)

Potential and limitations of PKA/ PKG inhibitors for platelet studies

Platelets, 2022
Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova, Natalia Rukoyatkina, Ulrich Walter, Stepan Gambaryan   +3 more
doaj   +2 more sources

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Cell Reports, 2017
Summary: Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA upon activation remain poorly understood.
Shane E. Tillo, Wei-Hong Xiong, Maho Takahashi, Sheng Miao, Adriana L. Andrade, Dale A. Fortin, Guang Yang, Maozhen Qin, Barbara F. Smoody, Philip J.S. Stork, Haining Zhong   +10 more
doaj   +2 more sources

Uni-pKa: An Accurate and Physically Consistent pKa Prediction through Protonation Ensemble Modeling [PDF]

, 2023
Predicting pKa values of small molecules has key applications in drug discovery and molecular simulation. However, current methods face challenges in rigorously interpreting experimental data and ensuring thermodynamic consistency between successive pKa
Zhengdan, Zhu, Hang, Zheng, Zhewei, Wei, Weiliang, Luo, Guolin, Ke, Gengmo, Zhou, Zhifeng, Gao   +6 more
core   +1 more source

MF-SuP-pKa: multi-fidelity modeling with subgraph pooling mechanism for pKa prediction [PDF]

, 2022
Acid-base dissociation constant (pKa) is a key physicochemical parameter in chemical science, especially in organic synthesis and drug discovery. Current methodologies for pKa prediction still suffer from limited applicability domain and lack of chemical
Yue, Wan, Tingjun, Hou, Chang-Yu, Hsieh, Dongsheng, Cao, Jialu, Wu, Zhenxing, Wu, Shengyu, Zhang, Jialu Wu, Tingjun Hou, Chang-Yu Hsieh, Zhenxing Wu, Shengyu Zhang, Dongsheng Cao, Yue Wan   +13 more
core   +2 more sources

Benchmarking pKa prediction [PDF]

, 2006
Background: pKa values are a measure of the protonation of ionizable groups in proteins. Ionizable groups are involved in intra-protein, protein-solvent and protein-ligand interactions as well as solubility, protein folding and catalytic activity.
Davies, M.N., Moss, David S, David S Moss, Davies, Matthew N, Moss, David S., Matthew N Davies, Toseland, C.P., Toseland, Christopher P, Christopher P Toseland, Flower, Darren R, Darren R Flower, Flower, D.R.   +11 more
core   +1 more source

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Surdo, N. C., Terrin, A., Sawa, A., N. E. Jordanides, A. Stangherlin, Monterisi, S., A. Terrin, Stefania Monterisi, Akira Sawa, Alessandra Stangherlin, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford, Zoccarato Anna, Zaccolo Manuela, Surdo Nicoletta C, Koschinski Andreas, Mongillo Marco, Mountford Joanne C, Stangherlin Alessandra, Monterisi Stefania, Jordanides Niove E, Sawa Akira, Terrin Anna   +43 more
core   +1 more source

pKa Determination of Strongly Acidic C-H Acids Bearing a (Perfluoroalkyl)sulfonyl Group in Acetonitrile by Means of Voltammetric Reduction of Quinone

Electrochemistry, 2021
A voltammetric method has been developed for the determination of the acid dissociation constant (pKa) of (RfSO2)2CHR (Rf = perfluoroalkyl), which is a strongly acidic molecule that serves as an acid catalyst.
Akira KOTANI, Hikaru YANAI, Takashi MATSUMOTO, Hideki HAKAMATA   +3 more
doaj   +1 more source

Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK

Adipocyte, 2020
The prevalence of obesity and its comorbidities has sparked a worldwide concern to address rates of adipose tissue accrual. Recent studies have demonstrated a novel role of Zyflamend, a blend of natural herbal extracts, in regulating lipid metabolism in ...
Dexter Puckett, Mohammed Alquraishi, Dina S. Alani, Samah Chahed, Victoria D. Frankel, Dallas Donohoe, Brynn Voy, Jay Whelan, Ahmed Bettaieb   +8 more
doaj   +1 more source

Synthesis of sulfacetamide and pKa calculation of its derivatives using ab initio methods [PDF]

شیمی کاربردی روز, 2018
Sulfonamides are a class of pharmaceutical compounds included –SO2NH– group that show a variety of biological activities. Sulfacetamide is an N-acyl sulfonamide that has broad-spectrum antibiotic effects.
Mohammad Reza Noorbala, Mansoor Namazian, Fatemah Tamaddon, Hamide Ajamein Ajamein   +3 more
doaj   +1 more source

Estimation of pKa, Analgesic, CNS Depressant Activities of Imidazolinone Derivatives By Correlation With Theoretical Parameters Based on Quantum Chemical Method [PDF]

مجلة التربية والعلم, 2018
Regression analysis is used for the estimation of the pKa values, %analgesic activity (%AA) and % decreasing activity of central nervous system (CNS) depressant property (%DA) of eight substituted imidazolin-5(4H)-ones by using various types of ...
Emad A. S. Al-Hyali
doaj   +1 more source