Cell Reports, 2017 Summary: Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA upon activation remain poorly understood.
Shane E. Tillo +10 more
doaj +2 more sources
Expert Opinion on Drug Metabolism & Toxicology, 2021 Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH-partition hypothesis form the theoretical base to define the impact of pH-pKa
G. Lu, Xiusheng Miao, Liu Dou
semanticscholar +1 more source
IPC 2.0: prediction of isoelectric point and pKa dissociation constants
Nucleic Acids Res., 2021 The isoelectric point is the pH at which a particular molecule is electrically neutral due to the equilibrium of positive and negative charges. In proteins and peptides, this depends on the dissociation constant (pKa) of charged groups of seven amino ...
L. Kozlowski
semanticscholar +1 more source
The regulation of PKA signaling in obesity and in the maintenance of metabolic health.
Pharmacology and Therapeutics, 2022 The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway throughout systems and across species. PKA facilitates the actions of hormones, neurotransmitters and other signaling molecules that bind G-protein coupled ...
E. London, Constantine A. Stratakis
semanticscholar +1 more source
Complex roles of cAMP–PKA–CREB signaling in cancer
Experimental Hematology & Oncology, 2020 Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which plays pivotal roles in cell signaling, and regulates many physiological and pathological processes.
Hongying Zhang +4 more
semanticscholar +1 more source
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
Biology Open, 2021 Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear.
Wanxu Guo +4 more
doaj +1 more source
Effect of warmed ropivacaine solution on onset and duration of axillary block [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundBicarbonate, as an adjunct increasing the non-ionized form of local anesthetics, can reduce latency and prolong duration of regional nerve block.
Rippy Lee +4 more
doaj +1 more source
A method for the determination of the dissociation constants of acids with an uncalibrated glass electrode [PDF]
, 1975 A method is presented for the determination of absolute pKa values of acids in solvents with a high dielectric constant by potentiometry with an uncalibrated glass electrode; in the determination, the glass electrode becomes calibrated.
Bos, M., Lengton, W.
core +11 more sources
Estimation of pKa, Analgesic, CNS Depressant Activities of Imidazolinone Derivatives By Correlation With Theoretical Parameters Based on Quantum Chemical Method [PDF]
مجلة التربية والعلم, 2018 Regression analysis is used for the estimation of the pKa values, %analgesic activity (%AA) and % decreasing activity of central nervous system (CNS) depressant property (%DA) of eight substituted imidazolin-5(4H)-ones by using various types of ...
Emad A. S. Al-Hyali
doaj +1 more source
Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]
, 2015 Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi +64 more
core +2 more sources