Results 21 to 30 of about 191,349 (283)

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
core   +1 more source

Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP

Cells, 2020
Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).
Alessandro Dema, Dörte Faust, Katina Lazarow, Marc Wippich, Martin Neuenschwander, Kerstin Zühlke, Andrea Geelhaar, Tamara Pallien, Eileen Hallscheidt, Jenny Eichhorst, Burkhard Wiesner, Hana Černecká, Oliver Popp, Philipp Mertins, Gunnar Dittmar, Jens Peter von Kries, Enno Klussmann   +16 more
doaj   +1 more source

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice [PDF]

Communications Biology, 2021
AbstractTemporal lobe epilepsy (TLE) is one of the most common and intractable neurological disorders in adults. Dysfunctional PKA signaling is causally linked to the TLE. However, the mechanism underlying PKA involves in epileptogenesis is still poorly understood.
Jingliang Zhang, Chenyu Zhang, Xiaoling Chen, Bingwei Wang, Weining Ma, Yang Yang, Ruimao Zheng, Zhuo Huang   +7 more
openaire   +3 more sources

Neuromodulation of excitatory synaptogenesis in striatal development

eLife, 2015
Dopamine is released in the striatum during development and impacts the activity of Protein Kinase A (PKA) in striatal spiny projection neurons (SPNs).
Yevgenia Kozorovitskiy, Rui Peixoto, Wengang Wang, Arpiar Saunders, Bernardo L Sabatini   +4 more
doaj   +1 more source

pKa Determination of Strongly Acidic C-H Acids Bearing a (Perfluoroalkyl)sulfonyl Group in Acetonitrile by Means of Voltammetric Reduction of Quinone

Electrochemistry, 2021
A voltammetric method has been developed for the determination of the acid dissociation constant (pKa) of (RfSO2)2CHR (Rf = perfluoroalkyl), which is a strongly acidic molecule that serves as an acid catalyst.
Akira KOTANI, Hikaru YANAI, Takashi MATSUMOTO, Hideki HAKAMATA   +3 more
doaj   +1 more source

MF-SuP-pKa: multi-fidelity modeling with subgraph pooling mechanism for pKa prediction [PDF]

, 2022
Acid-base dissociation constant (pKa) is a key physicochemical parameter in chemical science, especially in organic synthesis and drug discovery. Current methodologies for pKa prediction still suffer from limited applicability domain and lack of chemical
Yue, Wan, Tingjun, Hou, Chang-Yu, Hsieh, Dongsheng, Cao, Jialu, Wu, Zhenxing, Wu, Shengyu, Zhang   +6 more
core   +2 more sources

Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK

Adipocyte, 2020
The prevalence of obesity and its comorbidities has sparked a worldwide concern to address rates of adipose tissue accrual. Recent studies have demonstrated a novel role of Zyflamend, a blend of natural herbal extracts, in regulating lipid metabolism in ...
Dexter Puckett, Mohammed Alquraishi, Dina S. Alani, Samah Chahed, Victoria D. Frankel, Dallas Donohoe, Brynn Voy, Jay Whelan, Ahmed Bettaieb   +8 more
doaj   +1 more source

Synthesis of sulfacetamide and pKa calculation of its derivatives using ab initio methods [PDF]

شیمی کاربردی روز, 2018
Sulfonamides are a class of pharmaceutical compounds included –SO2NH– group that show a variety of biological activities. Sulfacetamide is an N-acyl sulfonamide that has broad-spectrum antibiotic effects.
Mohammad Reza Noorbala, Mansoor Namazian, Fatemah Tamaddon, Hamide Ajamein Ajamein   +3 more
doaj   +1 more source

Uni-pKa: An Accurate and Physically Consistent pKa Prediction through Protonation Ensemble Modeling [PDF]

, 2023
Predicting pKa values of small molecules has key applications in drug discovery and molecular simulation. However, current methods face challenges in rigorously interpreting experimental data and ensuring thermodynamic consistency between successive pKa
Zhengdan, Zhu, Hang, Zheng, Zhewei, Wei, Weiliang, Luo, Guolin, Ke, Gengmo, Zhou, Zhifeng, Gao   +6 more
core   +1 more source

Estimation of pKa, Analgesic, CNS Depressant Activities of Imidazolinone Derivatives By Correlation With Theoretical Parameters Based on Quantum Chemical Method [PDF]

مجلة التربية والعلم, 2018
Regression analysis is used for the estimation of the pKa values, %analgesic activity (%AA) and % decreasing activity of central nervous system (CNS) depressant property (%DA) of eight substituted imidazolin-5(4H)-ones by using various types of ...
Emad A. S. Al-Hyali
doaj   +1 more source