Journal of Taibah University for Science, 2022 Hybrid micellar liquid chromatography was used for practical determination of acid dissociation constant (pKa) of three analytes, namely, ibuprofen (IBU), naproxen (NPX) and benzoic acid (BZA).
M. E. K. Wahba, D. El Sherbiny
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Open-source QSAR models for pKa prediction using multiple machine learning approaches
Journal of Cheminformatics, 2019 BackgroundThe logarithmic acid dissociation constant pKa reflects the ionization of a chemical, which affects lipophilicity, solubility, protein binding, and ability to pass through the plasma membrane. Thus, pKa affects chemical absorption, distribution,
K. Mansouri +9 more
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Potential and limitations of PKA/ PKG inhibitors for platelet studies
Platelets, 2022 Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova +3 more
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Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]
, 2018 Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun +8 more
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WAVE2 Forms a Complex with PKA and Is Involved in PKA Enhancement of Membrane Protrusions [PDF]
Journal of Biological Chemistry, 2011 PKA contributes to many physiological processes, including glucose homeostasis and cell migration. The substrate specificity of PKA is low compared with other kinases; thus, complex formation with A-kinase-anchoring proteins is important for the localization of PKA in specific subcellular regions and the phosphorylation of specific substrates. Here, we
Hiroshi, Yamashita +2 more
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Cells, 2020 Best known as the powerhouse of the cell, mitochondria have many other important functions such as buffering intracellular calcium and reactive oxygen species levels, initiating apoptosis and supporting cell proliferation and survival.
Yujia Liu +2 more
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Alantolactone induces platelet apoptosis by activating the Akt pathway
Platelets, 2023 Alantolactone (ALT), a sesquiterpene lactone compound isolated from Inula helenium L., has recently attracted much attention for its anti-tumor properties.
Yueyue Sun +7 more
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Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]
, 2017 Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio +3 more
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Protein Kinase A(PKA)-Restrictcive and PKA-Permissive Phases of Oocyte Maturation [PDF]
Cell Cycle, 2005 Substantial evidence has indicated that cAMP-dependent protein kinase (protein kinase A or PKA) plays a critical role in maintaining meiotic prophase arrest in vertebrate oocytes. However, PKA activity dynamic and its physiological substrate profile during oocyte maturation remain poorly defined.
Jing, Wang +2 more
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Phase-dependent molecular requirements for memory reconsolidation: differential roles for protein synthesis and protein kinase A activity [PDF]
, 2006 After consolidation, a process that requires gene expression and protein synthesis, memories are stable and highly resistant to disruption by amnestic influences.
Kemenes, György +4 more
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