Results 41 to 50 of about 194,517 (249)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Nutrient sensing and cAMP signaling in yeast: G-protein coupled receptor versus transceptor activation of PKA

Microbial Cell, 2020
A major signal transduction pathway regulating cell growth and many associated physiological properties as a function of nutrient availability in the yeast Saccharomyces cerevisiae is the protein kinase A (PKA) pathway.
Griet Van Zeebroeck, Liesbeth Demuyser, Zhiqiang Zhang, Ines Cottignie, Johan M. Thevelein   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Characterization of a PKA-like kinase from Trypanosoma brucei [PDF]

, 2005
The protozoan parasite Trypanosoma brucei causes human sleeping sickness and Nagana in domestic animals and depends on the tsetse fly for dissemination. The complex T.
Kramer, Susanne
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]

, 2015
Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
O'Bryan, JP, Burmeister, BT, Wang, L, Gold, MG, Carnegie, GK, Skidgel, RA   +5 more
core  

RBC cAMP-PKA-dependent pathway and AT1R vs β-AR dimer/complex.

, 2019
RBC cAMP-PKA-dependent pathway and AT1R vs β-AR dimer/complex.
Jing Zhang (23775), George Lykotrafitis (3797242), Biree Andemariam (2513386), Sasia-Marie Jones (6588728)   +3 more
core   +1 more source

BAG2 interacts with DP and PKA-Cα.

, 2022
(a) Bag2 protein co-immunoprecipitates with DP and PKA-Cα using PKA antibody. (b) DP and PKA immunoprecipitate using BAG2 antibody. (c) Full-length blots represented in a and b panels.
Julian Kwan (9948515), Khashayar Vakili (12090931), Stephanie S. Kim (7230935), Elle Winter (12090925), Ranan G. Aktas (12090928), Yuxuan Wu (382359), Praveen Sethupathy (27692), Andrew Emili (65325), Anju Karki (840801), Michael Karski (12090919), Ina Kycia (12090916), Evan A. Bordt (9301585), Daniel E. Bauer (3198114), Rosanna K. Ma (12090922)   +13 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source