Results 61 to 70 of about 194,517 (249)

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Microtubule-associated type II protein kinase A is important for neurite elongation. [PDF]

PLoS ONE, 2013
Neuritogenesis is a process through which neurons generate their widespread axon and dendrites. The microtubule cytoskeleton plays crucial roles throughout neuritogenesis.
Yung-An Huang, Jun-Wei Kao, Dion Tzu-Huan Tseng, Wen-Shin Chen, Ming-Han Chiang, Eric Hwang   +5 more
doaj   +1 more source

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes [PDF]

, 2010
A-kinase anchoring proteins (AKAPs) tether protein kinase A (PKA) and other signaling proteins to defined intracellular sites, thereby establishing compartmentalized cAMP signaling.
Schmieder, Peter, Martin Bergmann, Miles D. Houslay, Joshi, Mangesh, Stephan Drewianka, Andrey Goncalves, Götz, Frank, Frank Christian, Frank Götz, Rosenthal, Walter, Klukovits Anna, Goetz, F., Rosenthal, W., Morano, Ingo, Bergmann, M., Houslay, Miles D., Marie Moutty, Vargas, Carolyn, Solveig Grossmann, Jens Peter von Kries, Zühlke Kerstin, Jens Furkert, Mangesh Joshi, Dmitry Kashin, Kerstin Zühlke, Zühlke, Kerstin, Dorothea Lorenz, Zimmermann, B., Zimmermann, Bastian, Lorenz Dorothea, Noack, Claudia, Goncalves, Andrey, Schmieder Peter, Bernd Reif, Kass, R., Houslay, M.D., Vargas, C., Morano, I., Goettert, H., Moutty, Marie, von Kries, J.P., Carolyn Vargas, Kornelia Hampel, Kass, Robert, Christian, Frank, Klussmann, E., Christian Frank, Genieser, H.G., Friedl, S., Lorenz, D., Baillie, G.S., Verli, J., Verli, Judit, Gáspár, Robert, Drewianka, S., Haase, Hannelore, Friedl Sabine, Drewianka Stephan, Claudia Noack, Walter Rosenthal, Noack, C., Bastian Zimmermann, Lorenz, Dorothea, Götz Frank, Moutty Marie, Grossmann, S., Kashin, Dmitry, Hans-Gottfried Genieser, Bergmann, Martin, Szaszak, M., Genieser, Hans-Gottfried, George S. Baillie, Goncalves Andrey, Furkert Jens, Anna Klukovits, Cooper, Dermot M.F., Reif, B., Baillie, George S., Herberg, F.W., Grossmann, Solveig, Márta Szaszák, Szaszák, Marta, Joshi, M., Furkert, J., Robert Kass, Schmieder, P., Klussmann, Enno, Cooper, Dermot M. F., Klukovits, A., Friedrich W. Herberg, Hampel, Kornelia, Róbert Gáspár, Dermot M.F. Cooper, Goncalves, A., Herberg, Friedrich W., Furkert, Jens, Zuehlke, K., Moutty, M., Enno Klussmann, Haase, H., Peter Schmieder, et al., Christian, F., Willoughby, Debbie, Reif, Bernd, Hampel, K., Gaspar, R., Göttert, Hendrikje, Klukovits, Anna, Hannelore Haase, Sabine Friedl, Szaszak Márta, Hendrikje Göttert, von Kries, Jens Peter, Ingo Morano, Willoughby, D., Friedl, Sabine, Vargas Carolyn, Judit Verli, Drewianka, Stephan, Gáspár Róbert, Verli Judit, Cooper, D.M., Debbie Willoughby, Kashin, D.   +124 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways

Open Medicine
Sepsis-associated encephalopathy (SAE) remains a major unmet clinical need, due to the lack of effective treatments. Although glutathione (GSH) is known for its antioxidant properties, its specific neuroprotective role via modulation of inflammatory ...
Wang Cailin, Liu Yong, Wen Xiangru, Lu Hui   +3 more
doaj   +1 more source

Methanesulfonic Acid as a Dual‐Role Reagent for Porous Polymer Network Design

Advanced Materials, EarlyView.
The design of porous polymer networks (PPNs) using methanesulfonic acid (MSA) as a dual‐role reagent facilitates the synthesis of robust PPNs for specific applications. It also makes the scale‐up process techno‐economically feasible because MSA functions simultaneously as both a solvent and a catalyst for the reaction.
Kelechi Festus, Arnab Ghosh, Ankit Mondal, Theresa Ariri, Suman Mandal, Ahana Sarkar, Urme Podder, Qingsheng Wang, Hong‐Cai Zhou   +8 more
wiley   +1 more source

Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the anti-melanogenic potential of ligustroside isolated from Ligustrum japonicum. Methods: The cytotoxicity of ligustroside was tested via MTT assay.
Xian-Rong Zhou, Fatih Karadeniz, Jung Hwan Oh, Youngwan Seo, Chang-Suk Kong   +4 more
doaj   +1 more source

Determination of Acid Dissociation Constants of Some 2-(3H) –Benzoxazolone Derivatives by UV–Vis Spectrophotometry [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The acid dissociation constant values of some 2-(3H)-benzoxazolone derivatives were determined in buffered solutions by using the UV-Vis spectrophotometric method.
Semra Altunterim Erkan, Hayati Celik, Banu Kesanlı   +2 more
doaj   +1 more source

Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]

PLoS Computational Biology, 2011
The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim, Alan Jung Park, Robbert Havekes, Andrew Chay, Leonardo Antonio Guercio, Rodrigo Freire Oliveira, Rodrigo Freire Oliveira, Ted Abel, Kim T Blackwell   +8 more
doaj   +1 more source

PKA function in DN1p neurons.

, 2014
(A) Reduction of PKA activity in DN1p has no effect on the phase of evening activity, but reduces morning anticipation. Graphs are as in Figure 1. Genotype (N). (A) Clk4.1-G4/+ (19), (B) Clk4.1-G4/U-PKA-R1dn (14).
Ravi Allada (82380), Elzbieta Kula-Eversole (5658388), Adam Seluzicki (538932), Valerie Kilman (538933), Luoying Zhang (223659), Matthieu Flourakis (356108)   +5 more
core   +1 more source