Results 61 to 70 of about 191,349 (283)

PKA compartmentalization links cAMP signaling and autophagy [PDF]

, 2021
Autophagy is a highly regulated degradative process crucial for maintaining cell homeostasis. This important catabolic mechanism can be nonspecific, but usually occurs with fine spatial selectivity (compartmentalization), engaging only specific ...
Surdo N. C., Grisan F., Iannucci L. F., Gerbino A., Di Benedetto G., Pozzan T., Zanin S., Lefkimmiatis K.   +7 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

RBC cAMP-PKA-dependent pathway and AT1R vs β-AR dimer/complex.

, 2019
RBC cAMP-PKA-dependent pathway and AT1R vs β-AR dimer/complex.
Jing Zhang (23775), George Lykotrafitis (3797242), Biree Andemariam (2513386), Sasia-Marie Jones (6588728)   +3 more
core   +1 more source

Implantable Ionic Memristors Based on Natural Polymer Heterojunctions

Advanced Functional Materials, EarlyView.
We report an implantable natural polymer‐based ionic memristor composed of hyaluronic acid, chitosan, and PDMS. The device achieved 98.94% accuracy in MNIST classification while reducing training time by 36.8% compared with a conventional artificial neural network (ANN).
Dong‐yup Lee, Byung Ik Park, Gihyeon Yim, Hyunjae Yoo, Sangjun Ma, Jundong Park, Jeong‐Yun Sun   +6 more
wiley   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

New components of the Dictyostelium PKA pathway revealed by Bayesian analysis of expression data [PDF]

, 2010
BACKGROUND: Identifying candidate genes in genetic networks is important for understanding regulation and biological function. Large gene expression datasets contain relevant information about genetic networks, but mining the data is not a trivial task ...
Kuspa Adam, Adam Kuspa, Zupan, Blaz, Dinh, Christopher, Gad Shaulsky, Christopher Dinh, Shaulsky, Gad, Eryong Huang, Parikh, Anup, Subramanian, Devika, Zupan Blaz, Parikh Anup, Devika Subramanian, Subramanian Devika, Dinh Christopher, Huang Eryong, Kuspa, Adam, Blaz Zupan, Anup Parikh, Shaulsky Gad, Huang, Eryong   +20 more
core   +2 more sources

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination

Cells, 2019
Background: During neuromuscular junction (NMJ) development, synapses are produced in excess. By sensing the activity-dependent release of ACh, adenosine, and neurotrophins, presynaptic receptors prompt axonal competition and loss of the unnecessary ...
Neus Garcia, Cori Balañà, Maria A. Lanuza, Marta Tomàs, Víctor Cilleros-Mañé, Laia Just-Borràs, Josep Tomàs   +6 more
doaj   +1 more source

STK25 inhibits PKA signaling by phosphorylating PRKAR1A [PDF]

, 2022
In the heart, protein kinase A (PKA) is critical for activating calcium handling and sarcomeric proteins in response to beta-adrenergic stimulation leading to increased myocardial contractility and performance.
Trevor R. Nash, Soni, Rajesh Kumar, Barry Fine, Rao, Jenny, Nash, Trevor R., Fine, Barry, Kim, Michael, Nash, Trevor, Liu, Bohao, Lock, Roberta, Soni, Rajesh, Zhang, Xiaokan, Bohao Liu, John Belov, Belov, John, Jenny Rao, Rajesh Kumar Soni, Xiaokan Zhang, Michael Kim, Manuel Tamargo, Wang, Bryan, Vunjak-Novakovic, Gordana, Tamargo, Manuel, Wang, Bryan Z., Li, Eric, Gordana Vunjak-Novakovic, Bryan Z. Wang, Eric Li, Roberta Lock   +28 more
core   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Menthol Increases Bendiocarb Efficacy Through Activation of Octopamine Receptors and Protein Kinase A

Molecules, 2019
Great effort is put into seeking a new and effective strategies to control insect pests. One of them is to combine natural products with chemical insecticides to increase their effectiveness.
Milena Jankowska, Justyna Wiśniewska, Łukasz Fałtynowicz, Bruno Lapied, Maria Stankiewicz   +4 more
doaj   +1 more source