Results 71 to 80 of about 194,517 (249)

Mapping Correlated Environmental Landscapes in the Fluorescence Response of a Pyrenylated Charge‐Transfer Probe via Data‐Driven Nonlinear Regression

Advanced Materials Interfaces, EarlyView.
A pyrenylated donor–acceptor probe exhibits environment‐dependent fluorescence governed by intramolecular charge transfer, restricted molecular motion, and supramolecular organization. Nonlinear regression accurately reconstructs fluorescence responses to viscosity, temperature, concentration, and pH, while correlated parameter maps reveal hidden ...
Harshal V. Barkale, Anakhi Hazarika, Nilanjan Dey   +2 more
wiley   +1 more source

PKA inhibits SUMOylation of Gli2 and Gli3.

, 2013
A. Co-immunoprecipitation assays performed in HEK293 cells co-transfected with HA-SUMO1, the indicated Glis and constitutively active PKA (PKA). Gli2 and Gli3 proteins were less SUMOylated in the presence of constitutively active PKA. B.
Barny Cox (362647), James Briscoe (34194), Fausto Ulloa (362649)   +2 more
core   +1 more source

Dynamic Fluorescence Modulation via Light‐Driven Competitive Protonation

Advanced Optical Materials, EarlyView.
A two‐component molecular system demonstrates reversible, light‐driven fluorescence write–erase cycling and thermal imaging. Illumination of a merocyanine photoacid transfers a proton to a highly efficient fluorescent pyridinium dye, switching its emission color; thermal relaxation reverses the process in the dark.
Serena X. Liu, Moritz E. Kleybolte, Colin van Dyck, Sergey I. Vagin, Preeti Gahtori, Antonio Scarpati, Razieh Firouzihaji, Diogo A. Galico, Ulrich S. Schubert, Julianne Gibbs, Alkiviathes Meldrum   +10 more
wiley   +1 more source

TOCP treatment reduces PKA activity.

, 2014
A. Flies treated with 16 mg/ml TOCP reveal a significant reduction in PKA activity in head extracts whereas flies treated with Paraoxon (PO; 0.2 mg/ml) show no change in PKA activity. B.
Jill S. Wentzell (308546), Doris Kretzschmar (308547), Marlène Cassar (523925)   +2 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Developmentally acquired PKA localisation in mouse oocytes and embryos

, 2008
<p>Localisation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate localised signalling complexes that target cAMP-mediated signalling to specific cellular sub-domains.
Lorna Tinworth, Manuela Zaccolo, Rachel J. Webb, Thomas, G.M., Geraint M.H. Thomas, Webb, R.J., Thomas, G.M.H., Tinworth, L., Zaccolo, M., John Carroll, Carroll, J.   +10 more
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Comparison of productive and carcass traits and economic value of lines selected for different criteria, slaughtered at similar weights

World Rabbit Science, 2016
The aim of the experiment was to compare 3 genetic groups, slaughtered at similar weights, to examine their productive and carcass traits and economic value.
K. Szendrő, ZS. Szendrő, ZS. Gerencsér, I. Radnai, P. Horn, ZS. Matics   +5 more
doaj   +1 more source

The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets

mBio, 2020
Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism.
E. Keats Shwab, Praveen R. Juvvadi, Greg Waitt, Shareef Shaheen, John Allen, Erik J. Soderblom, Benjamin G. Bobay, Yohannes G. Asfaw, M. Arthur Moseley, William J. Steinbach   +9 more
doaj   +1 more source

Structure of cAMP-PKA module.

, 2012
This module expresses the activation mechanism of PKA with cAMP. The PKA complex (R2C2) consists of two catalytic units and regulatory (inhibitory) units. External stimuli increase cAMP and four cAMP bind to R2C2.
Hiromu Takizawa (109306), Noriko Hiroi (109307), Akira Funahashi (109308)   +2 more
core   +1 more source