Results 91 to 100 of about 147,183 (245)

Origin of the unique topology of the triangular water cluster in Rubrobacter xylanophilus rhodopsin

Biophysics and Physicobiology
The crystal structure of Rubrobacter xylanophilus rhodopsin (RxR) reveals a triangular cluster of three water molecules (W413, W415, and W419) at the extracellular proton-release site, near Glu187 and Glu197.
Tomoyasu Noji, Masaki Tsujimura, Keisuke Saito, Keiichi Kojima, Yuki Sudo, Hiroshi Ishikita   +5 more
doaj   +1 more source

How cold is too cold? A theoretical analysis of the optimal trigger for index insurance for frost damage to crops

American Journal of Agricultural Economics, EarlyView.
Abstract Crop insurance is undoubtedly an extremely valuable element in protecting agricultural businesses, but in many cases standard indemnity‐based products have had very low uptake due to high transaction costs elevating premiums to unaffordable levels.
Amogh Prakasha Kumar, Laura Meriluoto, Richard Watt   +2 more
wiley   +1 more source

Exclusive Hydroformylation of Terminal Olefins: A Phosphorus‐Free Ruthenium System for the Selective Functionalization of Complex Mixtures

Angewandte Chemie, EarlyView.
Development of a phosphorus‐free Ru/DBU catalyst enabling highly chemo‐ and regioselective hydroformylation of terminal olefins, sparing internal double bonds. Optimization of reaction parameters, ligand effects, and substrate scope including industrial feedstocks was realized.
Mohamed Niyaz Vellala Syed Ali, Ida Ziccarelli, Dilver Peña Fuentes, Christoph Kubis, Robert Franke, Ralf Jackstell, Matthias Beller   +6 more
wiley   +2 more sources

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Carbohydrate Physicochemical Properties: The Innate Hydrogen Bond Donating Capacities of α‐Glucoside and α‐Galactoside Alcohol Groups

Angewandte Chemie, EarlyView.
Experimental determination of the innate hydrogen bond donating capacities of the glucose and galactose non‐anomeric alcohols revealed significant variations depending on position and relative configuration, which were quantified on the pKAHY scale, relevant for MedChem purposes, hence providing another tool toward rational glycomimetic development ...
Mrinal Naskar, Zhong Wang, Krunal Patel, Branko De Baets, Anaïs Goupille, Davy Sinnaeve, Eric Renault, Jean‐Yves Le Questel, Bruno Linclau   +8 more
wiley   +2 more sources

PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

eLife
Protein kinase A (PKA) plays essential roles in diverse cellular functions. However, the spatiotemporal dynamics of endogenous PKA upon activation remain debated.
Weihong Xiong, Maozhen Qin, Haining Zhong   +2 more
doaj   +1 more source

Synthese Unkonventioneller α‐Polyhalogenierter Amine Durch Hydroaminoalkylierung

Angewandte Chemie, EarlyView.
Es wird ein redox‐neutrales Verfahren beschrieben, bei dem Alkene und Alkine unter Verwendung stabiler Hemiaminal‐Reagenzien in α‐Polyhalogenmethylamine umgewandelt werden. Dieser Ansatz ermöglicht den Zugang zu α‐CF3‐, α‐CF2H‐, α‐CF2Cl‐, und α‐CFClH‐Aminen und besticht durch ein breites Substratspektrum, eine hohe Toleranz gegenüber funktionellen ...
Angela K. Hofmeister, Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, Nuno Maulide   +9 more
wiley   +1 more source

Precision Switching and Coupled Motion in a [3]Rotaxane Molecular Machine

Angewandte Chemie, EarlyView.
A [3]rotaxane, composed by two crown ether macrocycles and an axle presenting three recognition sites, is operated through both chemical and electrochemical stimuli. The position of the macrocycles is precisely controlled by sequential stimulation and the processes are fully reversible. The characterization of the system revealed the macrocycles affect
Leonardo Andreoni, Jessica Groppi, Alberto Credi, Serena Silvi   +3 more
wiley   +2 more sources

The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease

Signal Transduction and Targeted Therapy
Disrupted lipogenic signaling and steatosis are key features of alcohol-associated liver disease (ALD). A-kinase anchoring protein 12 (AKAP12) is a scaffolding partner of the cAMP-dependent protein kinase, PKA that controls its spatiotemporal ...
Chandana Thimme Gowda, Mallikarjuna Siraganahalli Eshwaraiah, Jiaohong Wang, Youngyi Lim, Maria Lauda Tomasi, Nirmala Mavila, Komal Ramani   +6 more
doaj   +1 more source

Spatiotemporal profiling of protein kinase A activity in spontaneously beating hiPSC-derived cardiac organoids

iScience
Summary: Protein kinase A (PKA) phosphorylates proteins crucial for rhythm modulation, with its dysregulation linked to arrhythmias. This study investigated PKA activity’s spatiotemporal dynamics in spontaneously beating cardiac organoids.
Ido Weiser-Bitoun, Savyon Mazgaoker, Rami Eid, Inbar Brosh, Yael Yaniv   +4 more
doaj   +1 more source