Results 111 to 120 of about 194,517 (249)

High‐Current‐Density Acidic CO2 Electroreduction to Formic Acid Enabled by Multiscale Microenvironment Regulation Over Defect‐Rich Sn/SnOx

Advanced Science, EarlyView.
Acidic CO2 electroreduction to formic acid is enabled by integrating mixed Sn/SnOx nanoclusters, K+‐regulated interfacial solvation, and Janus wettability. Coordinated control of active sites, interfacial water, and gas‐liquid transport suppresses hydrogen evolution and delivers approximately 85% HCOOH Faradaic efficiency at 400 mA cm−2.
Qiaoqi Guo, Bowen Jiang, Le Huang, Kunyu Jiang, Rongrong Tang, Qinong Zhu, Huajun Feng, Mengyang Fan, Yijing Xia   +8 more
wiley   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Protein pKa and Cu(I) Binding

, 2021
Protein PKA and protein-metal binding constraints of Zn(II) ions are scarce in literature and not abundantly kept in one place. It is even harder to find a list of such constants correlated with the corresponding PDB structures.
Raymond, Greggory W.
core   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair

Advanced Science, EarlyView.
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng, Wei Li, Yawei Li, Zhiming Tu, Hong Ma, Yuliang Dai, Zhaoling Ma, Tao Yuan, Bing Wang   +8 more
wiley   +1 more source

Origin of the unique topology of the triangular water cluster in Rubrobacter xylanophilus rhodopsin

Biophysics and Physicobiology
The crystal structure of Rubrobacter xylanophilus rhodopsin (RxR) reveals a triangular cluster of three water molecules (W413, W415, and W419) at the extracellular proton-release site, near Glu187 and Glu197.
Tomoyasu Noji, Masaki Tsujimura, Keisuke Saito, Keiichi Kojima, Yuki Sudo, Hiroshi Ishikita   +5 more
doaj   +1 more source

Peptide-based development of PKA activators

, 2018
Protein kinases are among the most important regulators of cellular homeostasis, regulating many aspects of the cell life cycle through phosphorylation. The threonine/serine kinase cAMP-dependent protein kinase (PKA) is a major intracellular effector for
Colotti Gianni, Maimoun David, Shenberger Yulia, Shainberg Asher, Ruthstein Sharon, Zhenin Michael, Kahremany Shirin, Arad Michael, Gruzman Arie, Senderowitz Hanoch   +9 more
core   +1 more source

Linker‐Locking Strategy for the Rigidification of Flexible Metal–Organic Framework: Structural Stabilization and Controlled ESIPT for H2O/D2O Sensing

Advanced Science, EarlyView.
A linker‐locking strategy rigidifies the flexible metal–organic framework (MOF) MIL‐53‐(OH)2 via the cooperative encapsulation of ligands and structural water. This network significantly enhances the framework's aqueous stability. Crucially, rigidification suppresses enol emission to yield a single keto tautomer state with an extended lifetime ...
Amitosh Sharma, Seonghwan Lee, Seo I Park, Hak‐Won Nho, Junmo Seong, Eunseo Lee, Oh‐Hoon Kwon, Myoung Soo Lah, Jaewoong Lim   +8 more
wiley   +1 more source

STAD-2 does not associate with PKA.

, 2015
(A) Late-stage iRBC were treated with 1 μM FITC-conjugated STAD-2 for 2 hours and probed for P. falciparum PKA-R (top panel) or H. sapiens PKA-RII (bottom panel). STAD-2 did not show clear colocalization with either of the regulatory subunits.
Vasant Muralidharan (449197), Briana R. Flaherty (744995), Tienhuei G. Ho (744997), Yuxiao Wang (235398), Eileen J. Kennedy (374107), David S. Peterson (184376), Edward C. Trope (744996)   +6 more
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source