Results 131 to 140 of about 191,349 (283)

COMPUTATIONAL PREDICTION OF pKa VALUES OF MORIN

, 2022
Favonoid morin, nazvan prema biljnoj porodici Moraceae (dudovke), predmet je brojnih znanstvenih istraživanja. Ovaj prehrambeni bioflavonoid pokazuje niz različitih bioaktivnosti, kao što su antioksidacijska, protuupalna, neuroprotektivna, kardio ...
Amić, Ana, Cepanec, Matija
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Origin of the unique topology of the triangular water cluster in Rubrobacter xylanophilus rhodopsin

Biophysics and Physicobiology
The crystal structure of Rubrobacter xylanophilus rhodopsin (RxR) reveals a triangular cluster of three water molecules (W413, W415, and W419) at the extracellular proton-release site, near Glu187 and Glu197.
Tomoyasu Noji, Masaki Tsujimura, Keisuke Saito, Keiichi Kojima, Yuki Sudo, Hiroshi Ishikita   +5 more
doaj   +1 more source

Supramolecular Terbium‐Threonine Chiral Emitters with Tunable Circularly Polarized Luminescence as Anticounterfeiting‐Ink for Autonomous Data Encryption

Advanced Science, EarlyView.
A one‐pot, aqueous, and scalable method for synthesizing chiral lanthanide supramolecular emitters using terbium and threonine is reported. The aqueous solution of these chiral emitters displays the following features: (i) 100 % transparency, (ii) tunable luminescence and CPL, and (iii) a pH feedback loop that controls the “on‐off” states of ...
P. M. Ajay Sekhar, Nidhin Ravi, Kaloor S. Harikrishnan, Jim Bachmann, Nikos L. Doltsinis, Reji Varghese   +5 more
wiley   +1 more source

Cordyceps sinensis mycelium activates PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse Leydig tumor cells

, 2012
[[abstract]]Cordyceps sinensis (CS) mycelium stimulates steroidogenesis in MA-10 mouse Leydig tumor cells, but the mechanisms remain unclear. In this study, MA-10 cells were treated with different reagents in the presence or absence of CS (10 mg/ml) for ...
黃元勵;Huang, Yuan-Li
core  

PKA-C3 and SWSR^133A expression prevent TOCP-induced reduction in PKA activity.

, 2014
A. PKA-C3 overexpression increases PKA activity and this is not affected by TOCP treatment. B. Additional expression of SWS significantly reduces PKA activity whereas heterozygosity for sws1 does not.
Jill S. Wentzell (308546), Doris Kretzschmar (308547), Marlène Cassar (523925)   +2 more
core   +1 more source

GENI COINVOLTI NELLA TRASMISSIONE DEI SEGNALI CAMP E RAS. MANIPOLAZIONE DELLA LORO ESPRESSIONE ED ATTIVIT`. TERAPIA GENICA SOMATICA

, 1999
1. Isolamento di proteine AKAP specifiche di tessuto (tiroide, cuore, endotelio e colon) che legano PKA sul mitocondrio, Golgi e citoscheletro. Saranno costruiti mutanti dominanti negativi e positivi che inibiscono od attivano il circuito di segnalazione
AVVEDIMENTO, VITTORIO ENRICO
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Correlated Polymer‐Proton Hopping Enables Water‐Independent Fast Proton Transport in Poly(Ionic Liquid) Membranes

Advanced Science, EarlyView.
A polymer chain in motion: backbone, ring, and counterion dynamics interlock across timescales to relay protons through poly(ionic liquid) membranes. ABSTRACT Polymer electrolyte membranes composed of ionic liquids (IL), capable of conducting protons efficiently at elevated temperatures, without external humidification, could transform fuel cell ...
Keenan Smith, Antonela Gallastegui, Zixuan Yu, Yuliana Pairetti, Andrew Seel, Jacques Ollivier, Victoria Garcia Sakai, Bob C. Schroeder, Maria Forsyth, Aurelie Gueguen, David Mecerreyes, Fabrizia Foglia   +11 more
wiley   +1 more source

Disruption of PKA anchoring, as caused by Ht31 peptide, decreases PKA phosphorylation of downstream targets.

, 2012
When adenylate cyclase (AC) is in the spine, disruption of PKA anchoring reduces by 30% both phosphoThr34 DARPP-32 (p = 0.0006) and phosphoSer845 GluA1 (p = 0.0036).
MyungSook Kim (65534), Kim T. Blackwell (169701), Rodrigo F. Oliveira (184716)   +2 more
core   +1 more source