Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. [PDF]
, 2018 G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in a broad range of physiological responses and disease states. Activated GPCRs can undergo agonist-induced phosphorylation by G protein receptor kinases (GRKs) and second ...
Chowdhury, Dhrubajyoti +8 more
core +3 more sources
Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery
Advanced Healthcare Materials, EarlyView.A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu +7 more
wiley +1 more source
Determination of Acid Dissociation Constants of Some 2-(3H) –Benzoxazolone Derivatives by UV–Vis Spectrophotometry [PDF]
Iranian Journal of Chemistry & Chemical EngineeringThe acid dissociation constant values of some 2-(3H)-benzoxazolone derivatives were determined in buffered solutions by using the UV-Vis spectrophotometric method.
Semra Altunterim Erkan +2 more
doaj +1 more source
mBio, 2020 Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism.
E. Keats Shwab +9 more
doaj +1 more source
Involvement of Protein Kinase C and Protein Kinase A in the Enhancement of L-type Calcium Current by GABA\u3csub\u3eB\u3c/sub\u3e Receptor Activation in Neonatal Hippocampus [PDF]
, 2011 In the early neonatal period activation of GABAB receptors attenuates calcium current through N-type calcium channels while enhancing current through L-type calcium channels in rat hippocampal neurons.
Bray, Jennifer Grace, Mynlieff, Michelle
core +1 more source
Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
Cell Reports, 2016 SUMMARY Cells adopt distinct signaling pathways to optimize cell locomotion in different physical microenvironments. However, the underlying mechanism that enables cells to sense and respond to physical confinement is unknown.
W. Hung +13 more
semanticscholar +1 more source
Thiolated Polymers in 3D Bioprinting: Control of Gelation
Advanced Materials, EarlyView.Thiolated polymers are established as programmable bioinks for 3D bioprinting, integrating versatile crosslinking chemistries with redox‐responsive control. This work demonstrates how molecular design and external triggers define gelation kinetics, printability windows, and structural fidelity, enabling stable, high‐resolution constructs and advancing ...
Soheil Haddadzadegan +2 more
wiley +1 more source
Extinction of gene expression in somatic cell hybrids. a reflection of important regulatory mechanisms? [PDF]
, 1993 Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell
Boshart, Michael +2 more
core +1 more source
Reining in uncontrolled inflammasome with PKA
Nature Immunology, 2016 During the course of infection, the detection of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by pattern-recognition receptors (PRRs) can lead to inflammasome formation, with subsequent activation of ccaspase-1, secretion of interleukin 1β (IL-1β) and IL-18, and cell death via pyroptosis.
Karen V, Swanson, Jenny P-Y, Ting
openaire +3 more sources
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Molecular Brain, 2012 The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world.
E. Kandel
semanticscholar +1 more source