Results 101 to 110 of about 194,517 (249)
Advanced Science, EarlyView.A one‐pot, aqueous, and scalable method for synthesizing chiral lanthanide supramolecular emitters using terbium and threonine is reported. The aqueous solution of these chiral emitters displays the following features: (i) 100 % transparency, (ii) tunable luminescence and CPL, and (iii) a pH feedback loop that controls the “on‐off” states of ...
P. M. Ajay Sekhar +5 more
wiley +1 more source
Model: AKAP degradation is dependent on PKA anchoring.
, 2013 At the beginning of capacitation (top left), the AKAP3-PKARII - PKAC complex is intact. Under these conditions AKAP3 is not degraded. During the capacitation process, bicarbonate activates sAC to generate cAMP which binds to the regulatory subunits ...
Haim Breitbart (436035) +3 more
core +1 more source
Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Advanced Science, EarlyView.A polymer chain in motion: backbone, ring, and counterion dynamics interlock across timescales to relay protons through poly(ionic liquid) membranes. ABSTRACT Polymer electrolyte membranes composed of ionic liquids (IL), capable of conducting protons efficiently at elevated temperatures, without external humidification, could transform fuel cell ...
Keenan Smith +11 more
wiley +1 more source
Advanced Science, EarlyView.Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge +13 more
wiley +1 more source
Control of PKA signaling by the Ubiquitin proteasome system (UPS) [PDF]
, 2016 Stimulation of G protein coupled receptors(GPCRs) causes the increase of cAMP intracellular levels. The main effector of cAMP signaling is Protein kinase A (PKA), which, in its inactive form, is constituted by two catalytic (Cs) and two regulatory (Rs ...
Rinaldi, Laura
core +1 more source
PKA-C3 and SWSR133A expression prevent TOCP-induced reduction in PKA activity.
, 2014 A. PKA-C3 overexpression increases PKA activity and this is not affected by TOCP treatment. B. Additional expression of SWS significantly reduces PKA activity whereas heterozygosity for sws1 does not.
Jill S. Wentzell (308546) +2 more
core +1 more source
Advanced Science, EarlyView.Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu +18 more
wiley +1 more source
cis‐Carboxylate Enhancement of Mn(III)‐OH Hydrogen Atom Abstraction through PCET Thermodynamics [PDF]
Advanced scienceABSTRACT Manganese(III)‐hydroxo intermediates are proposed as key hydrogen atom abstraction (HAA) species in manganese‐dependent enzymes, yet how first‐sphere carboxylate ligands control their proton‐coupled electron transfer (PCET) thermodynamics remains poorly understood.
Lee Y, Sim Y, An S, Cho K, Cho J.
europepmc +2 more sources
Screening for small molecule disruptors of AKAP-PKA interactions
, 2015 Protein-protein interactions (PPIs) are highly specific and diverse. Their selective inhibition with peptides, peptidomimetics, or small molecules allows determination of functions of individual PPIs.
João Miguel Parente Fernandes +11 more
core +1 more source