Results 31 to 40 of about 191,349 (283)

Potentiometric investigation of acid-base equilibria of two new pyrimidine derivatives in various methanol-water media [PDF]

Journal of the Serbian Chemical Society, 2006
The acid-base properties of 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-one (L1) and 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-thione (L2) were investigated potentiometrically at an ionic strength of 0.10M(LiCl) in 19.8, 33.6 and 55.9 % (v/v) methanol ...
Kiliç Hasan, Birol Er
doaj   +1 more source

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Huang, T., Day, Jonathan P., Day, Jonathan P, Baillie, George S., Guercio, L.A., Luczak, V., Nie, T., Scott, J.D., Guercio, Leonardo A., Baillie, G.S., Abel, T., Gelman, I.H., Park, Alan J, Canton, David A., Scott, John D., Havekes, R., Nie, Ting, Gelman, Irwin H, Canton, D.A., Park, Alan J., Grimes, Quinn, Grimes, Q., Luczak, Vincent G, Havekes, Robbert, Park, A.J., Guercio, Leonardo A, Baillie, George S, Abel, Ted, Gelman, Irwin H., Luczak, Vincent, Day, J.P., Canton, David A, Huang, Ted   +32 more
core   +1 more source

DataSheet_1_Lactate increases tumor malignancy by promoting tumor small extracellular vesicles production via the GPR81-cAMP-PKA-HIF-1α axis.docx

, 2022
Lactate and tumor cell-derived extracellular vesicles (TEVs) both contribute to tumor progression. However, it is still unclear whether lactate can accelerate tumor development by directly promoting TEV production.
Yuxiao Tong (14201876), Junqi Zhu (13918596), Man Luo (105740), Limin Wang (87511), Jie Ren (176083), Jiaoli Wang (740874), Shenglin Ma (499605)   +6 more
core   +1 more source

Effect of warmed ropivacaine solution on onset and duration of axillary block [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundBicarbonate, as an adjunct increasing the non-ionized form of local anesthetics, can reduce latency and prolong duration of regional nerve block.
Rippy Lee, Young Mi Kim, Eun Mi Choi, Young Ryong Choi, Mi Hwa Chung   +4 more
doaj   +1 more source

Overview of the SAMPL6 pKa challenge: evaluating small molecule microscopic and macroscopic pKa predictions [PDF]

, 2021
The prediction of acid dissociation constants (pKa) is a prerequisite for predicting many other properties of a small molecule, such as its protein-ligand binding affinity, distribution coefficient (log D), membrane permeability, and solubility. The
Işık, Mehtap, Mobley, David L, Rizzi, Andrea, Chodera, John D, Gunner, MR, Rustenburg, Ariën S   +5 more
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung-tropic mRNA Delivery and pH-Programmed Endosomal Escape. [PDF]

Adv Sci (Weinh)
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Lim SG, Lee M, Wang Y, Choi E, Park JS, Park K, Jeon H, Kim D, Lee D, Lee Y, Kim KP, Kim E, Koo H.   +12 more
europepmc   +2 more sources

Predicting the pKa Values of the Deprotonation Equilibria of Benzenonium Carbocations

, 2022
The pKa(H) value of the benzenonium carbocation (C6H7+, cy-clohexadienyl cation, Wheland intermediate) is −24.3 [1]. The Hammett’s reaction constant (ρ) value for the deprotonation equilibrium is 14.3 [2].
Sanjeeva, R, Geelan, David, Jagannadham, V   +2 more
core   +1 more source

The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations [PDF]

, 2010
Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite ...
Terrin, A., Terrin, A, Zaccolo Manuela, Rodrigo F Oliveira, Oliveira Rodrigo F., Kim, M., Blackwell, K., Cannon, R.C., Kim T Blackwell, Oliveira, RF, Wonryull Koh, Di Benedetto Giulietta, Kim MyungSook, Giulietta Di Benedetto, Manuela Zaccolo, Zaccolo, M, Cannon, RC, Terrin Anna, MyungSook Kim, Zaccolo, Manuela, Anna Terrin, Robert C Cannon, Di Benedetto, G., Cannon Robert C., Koh, K., Robert C. Cannon, Di Benedetto, G, Koh Wonryull, Zaccolo, M., Koh, W, Blackwell Kim T., Kim T. Blackwell, Rodrigo F. Oliveira, Oliveira, R.F., Kim, M, Blackwell, KT   +35 more
core   +2 more sources

Control of PKA stability and signalling by RING ligase praja2 [PDF]

, 2010
Ligand-mediated activation of G-Protein Coupled Receptors (GPCRs) mobilises compartmentalised pulses of second messengers like cAMP. The main cellular effector of cAMP is Protein Kinase A (PKA) which is assembled as inactive holoenzyme consisting of two ...
Lignitto, Luca
core   +1 more source

Developmentally acquired PKA localisation in mouse oocytes and embryos [PDF]

, 2008
<p>Localisation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate localised signalling complexes that target cAMP-mediated signalling to specific cellular sub-domains.
Thomas, GM, Thomas, Geraint M.H., Zaccolo, M, Lorna Tinworth, Manuela Zaccolo, Rachel J. Webb, Thomas, G.M., Carroll, J, Zaccolo, Manuela, Webb, RJ, Geraint M.H. Thomas, Webb, R.J., Thomas, G.M.H., Tinworth, L, Webb, Rachel J., Tinworth, L., Zaccolo, M., John Carroll, Carroll, J., Tinworth, Lorna, Carroll, John   +20 more
core   +1 more source