Results 31 to 40 of about 194,517 (249)

Centrally formed acetaldehyde mediates ethanol-induced brain PKA activation [PDF]

, 2014
Centrally formed acetaldehyde has proven to be responsible for several psychopharmacological effects induced by ethanol. In addition, it has been suggested that the cAMP-PKA signaling transduction pathway plays an important role in the modulation of ...
González Aragón, Carlos Manuel, Tarragon Cros, Ernesto, Baliño, Pablo   +2 more
core   +1 more source

Exploring the pKa, Molecular Binding, and Caspase-3 Activation Potential of Coumarin Derivatives [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Caspase-3 is a central executioner protease in apoptosis, and its activation by small molecules is considered a promising anticancer strategy. Coumarin derivatives are known for their diverse biological activities, but the influence of structural ...
Semra Altunterim Erkan, Emine Erdag, Louai Alsaloumi, Hayati Celik   +3 more
doaj   +1 more source

AKAP18 PKA RII alpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA [PDF]

, 2016
A-kinase anchoring proteins (AKAPs) interact with the dimerization/docking (D/D) domains of regulatory subunits of the ubiquitous protein kinase A (PKA).
Herberg, F.W., Krause, Gerd, Götz, Frank, Schulz, Maike Svenja, Kennedy, Eileen J., Roske, Y., Goetz, F., Klussmann, E., Heinemann, Udo, Bertinetti, D., Kreuchwig, A., Roske, Yvette, Kreuchwig, Annika, Daumke, O., Klussmann, Enno, Götz, F., Krause, G., Schulz, M.S., Heinemann, U., Daumke, Oliver, Kennedy, E., Bertinetti, Daniela, Herberg, Friedrich W., Zühlke, Kerstin, Faelber, Katja, Zuehlke, K., Zühlke, K., Autenrieth, K., Faelber, K., Autenrieth, Karolin   +29 more
core   +1 more source

Theoretical investigation of cyclooxygenase inhibition property of several non-steroidal anti-inflammatory drugs by density functional theory calculations and molecular docking studies [PDF]

Trends in Pharmaceutical Sciences, 2015
Understanding the geometry, electronic properties of non-steroidal anti-inflammatory drugs (NSAIDs) and the nature of their interactions with human cyclooxygenase-2 (COX-2) is important in development and design of novel NSAIDs.
Atena Najdian, Amirhossein Sakhteman, Maryam Mortazavi, Hossein Sadeghpour, Massoud Amanlou   +4 more
doaj  

Conceptual DFT as a Novel Chemoinformatics Tool for Studying the Chemical Reactivity Properties of the Amatoxin Family of Fungal Peptides

Open Chemistry, 2019
The chemical structures and molecular reactivities of the Amatoxin group of fungi-derived peptides have been determined by means of the consideration of a model chemistry that has been previously validated as well-behaved for our purposes. The reactivity
Flores-Holguín Norma, Frau Juan, Glossman-Mitnik Daniel   +2 more
doaj   +1 more source

Output-files-pka-COOH

, 2016
All the output files for the calculations of pKa values.
Annia Galano (3224100)
core   +1 more source

A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease

Cells, 2020
Best known as the powerhouse of the cell, mitochondria have many other important functions such as buffering intracellular calcium and reactive oxygen species levels, initiating apoptosis and supporting cell proliferation and survival.
Yujia Liu, Ronald A. Merrill, Stefan Strack   +2 more
doaj   +1 more source

Alantolactone induces platelet apoptosis by activating the Akt pathway

Platelets, 2023
Alantolactone (ALT), a sesquiterpene lactone compound isolated from Inula helenium L., has recently attracted much attention for its anti-tumor properties.
Yueyue Sun, Mengnan Yang, Shujun Li, Ying Hu, Biao Yang, Xu Li, Rong Yan, Kesheng Dai   +7 more
doaj   +1 more source

Comparison of pKa values for oxy-enzymase derivatives derived from 3-acetyl and 4-acetyl-3 serotonin by using glass pole [PDF]

مجلة التربية والعلم, 2014
The study includes the preparation of four syn and anti oximes derived from mother ketones, namely 3-acetyl and 4-acetyl pyridine by standard method. The structures of these oximes were confirmed by using UV and IR spectra, melting points and specific ...
Adel Azzoz, rawaa Suliaman
doaj   +1 more source

STK25 inhibits PKA signaling by phosphorylating PRKAR1A [PDF]

, 2022
In the heart, protein kinase A (PKA) is critical for activating calcium handling and sarcomeric proteins in response to beta-adrenergic stimulation leading to increased myocardial contractility and performance.
Trevor R. Nash, Soni, Rajesh Kumar, Barry Fine, Rao, Jenny, Nash, Trevor R., Fine, Barry, Kim, Michael, Liu, Bohao, Lock, Roberta, Zhang, Xiaokan, Bohao Liu, John Belov, Belov, John, Jenny Rao, Rajesh Kumar Soni, Xiaokan Zhang, Michael Kim, Manuel Tamargo, Vunjak-Novakovic, Gordana, Tamargo, Manuel, Wang, Bryan Z., Li, Eric, Gordana Vunjak-Novakovic, Bryan Z. Wang, Eric Li, Roberta Lock, Nash, Trevor R, Wang, Bryan Z   +27 more
core   +1 more source