Results 91 to 100 of about 18,395 (198)

Automated Metadata Review to Support Result Release in Quantitative Liquid Chromatography Coupled With Tandem Mass Spectrometry Applications

Analytical Science Advances, Volume 7, Issue 2, December 2026.
Quantitative isotope‐dilution liquid chromatography coupled with tandem mass spectrometry analyses generate extensive metadata that require time‐consuming manual validation in laboratory workflows. We developed MSVal, an Excel‐based tool that applies predefined quality criteria to automatically evaluate results and highlight deviations.
Verena Endt, Katharina Habler, Michael Vogeser   +2 more
wiley   +1 more source

Stimuli-Responsive DNA Hydrogel Design Strategies for Biomedical Applications

Biosensors
Hydrogels are three-dimensional network structures composed of hydrophilic polymers that can swell in water and are very similar to soft tissues such as connective tissue or the extracellular matrix.
Minhyuk Lee, Minjae Lee, Sungjee Kim, Nokyoung Park   +3 more
doaj   +1 more source

Advances in the Design and Functionality of a Compact Multi‐Reflecting Time‐of‐Flight Mass Spectrometer

Rapid Communications in Mass Spectrometry, Volume 40, Issue 22, 30 November 2026.
ABSTRACT Rationale High‐resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications demand instrumentation to be capable of combining sub‐ppm mass accuracy, high resolving power, rapid full m/z range acquisition over a wide dynamic range.
Jason Wildgoose, Samantha Ferries, Lee A. Gethings, Matthew E. Daly, Martin E. Palmer, Richard Lock, Johannes P. C. Vissers, James I. Langridge   +7 more
wiley   +1 more source

Roxadustat as a Hypoxia-Mimetic Agent: Erythropoietic Mechanisms, Bioanalytical Detection, and Regulatory Considerations in Sports Medicine

Current Issues in Molecular Biology
Roxadustat (ROX) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHI) that exerts erythropoietic, cardioprotective, and metabolic regulatory effects.
Elena-Christen Creangă, Cristina Ott, Alina-Crenguţa Nicolae, Cristina Manuela Drăgoi, Raluca Stan   +4 more
doaj   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source

Bioanalysis in drug discovery and development

, 2010
Recent years have witnessed the introduction of several high-quality review articles into the literature covering various scientific and technical aspects of bioanalysis.
Pandey, Preeti, Tiwari, Gaurav, Pandey, Saurabh, Tiwari, Ruchi   +3 more
core   +1 more source

Quantitation of Cirtuvivint (SM08502) in Human Plasma by LC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT CDC‐like kinases (CLK) and dual‐specificity tyrosine‐regulated kinases (DYRK) are protein kinases involved in various cellular functions, mRNA splicing, and DNA damage repair. CLK/DYRK kinases have been implicated in many disorders such as diabetes, neurodegenerative diseases, and cancer.
Julianne L. Holleran, Joshua J. Deppas, Ye Feng, Michael J. Hochman, Evan C. Chen, Maximilian Stahl, Steven D. Gore, Timothy W. Synold, Jan H. Beumer, Raman Venkataramanan, Robert A. Parise   +10 more
wiley   +1 more source

Bioanalytical HPLC-UV Determination of Dopamine in Plasma and Mouse Brain Homogenate with Greenness, Whiteness, and Blueness Assessment

Molecules
Dopamine dysregulation is connected to several neurological disorders, including Parkinson’s disease, Huntington’s disease, and addiction. A new, precise, accurate, and specific reversed-phase high-performance liquid chromatographic method was developed ...
Miglena Smerikarova, Stanislav Bozhanov, Jana Tchekalarova, Petja Ivanova, Violina T. Angelova, Vania Maslarska   +5 more
doaj   +1 more source

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3498-3505, October 2026.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Analytical Strategies for the Determination of Dapagliflozin in Pharmaceutical and Biological Matrices: A Comprehensive Review

Scientia Pharmaceutica
Dapagliflozin (DAPA), a selective sodium–glucose cotransporter 2 inhibitor, is widely used in the management of type 2 diabetes mellitus, with additional indications in heart failure and chronic kidney disease.
Ecaterina Gliga, Denisa Gabriela Stroia, Gabriel Hancu, Eleonora Mircia   +3 more
doaj   +1 more source