Results 31 to 40 of about 18,395 (198)

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies

Journal of Pharmacy and Bioallied Sciences, 2013
Background: The use of anti-histaminic agents has been increased significantly from last decades and till now no method is available for quantitation of ALZ in human plasma which can be applied in a bioequivalence study using LC-MS/MS.
Bhupinder Singh, Sandeep Sharma, Naveen Dubey, Ashish Dwivedi, Rama S Lokhandae   +4 more
doaj   +1 more source

Current Development in Bioanalytical Sample Preparation Techniques

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2023
The preparation of the sample is the most important stage in bioanalysis. Proteins, salts, and other organic compounds with chemical characteristics similar to the target analytes are commonly found in biological samples.
SAKSHI SANGALE SAKSHI, PRAVIN R. DIGHE, MANOJ R KUMBHARE   +2 more
doaj   +1 more source

Exploring fluoropolymers for fabrication of femtoliter chamber arrays used in digital bioanalysis

Scientific Reports
The global supply of fluoropolymers and fluorinated solvents is decreasing due to environmental concerns regarding polyfluoroalkyl substances. CYTOP has been used for decades primarily as a component of a femtoliter chamber array for digital bioanalysis;
Jun Ando, Kazue Murai, Makiko Mori, Tomoe Michiyuki, Tatsuya Iida, Asami Makino, Hajime Shinoda, Rikiya Watanabe   +7 more
doaj   +1 more source

Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis

Separations, 2023
Since inflammatory bowel disease is a progressive disease, optimal treatment early in the disease course is paramount. Still, the use of conventional drugs is accompanied by side effects.
Jelena Kovačić, Mario-Livio Jeličić, Daniela Amidžić Klarić, Ana Mornar   +3 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines ‘Scientific’? : Part 1 – LCMS: small molecules, peptides and small molecule biomarkers

, 2017
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California on 3–7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology ...
Coppola, Laura, Welink, Jan, Hughes, Nicola, Woolf, Eric, et. al., Kurki, Pekka, Yang, Eric, Sydor, Jens, Rago, Brian   +8 more
core   +1 more source

Optimization of Preparation and Preclinical Pharmacokinetics of Celastrol-Encapsulated Silk Fibroin Nanoparticles in the Rat

Molecules, 2019
Celastrol (CL), a bioactive compound isolated from Tripterygium wilfordii, has demonstrated bioactivities against a variety of diseases including cancer and obesity.
Felicia Onyeabor, Amy Paik, Surya Kovvasu, Baoyue Ding, Jelissa Lin, Md Arif Wahid, Sunil Prabhu, Guru Betageri, Jeffrey Wang   +8 more
doaj   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

2017 White Paper on recent issues in bioanalysis: rise of hybrid LBA/LCMS immunogenicity assays : Part 2: hybrid LBA/LCMS biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies’ inputs

, 2017
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California on 3–7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology ...
Neubert, Henrik, Lee, Anita, et.al., Duggan, Jeff, Wei, Cong, Song, AN, Kurki, Pekka, Keyang, Xu   +7 more
core   +1 more source