Results 61 to 70 of about 18,395 (198)

Bacterial backpacks for targeted delivery of piezoelectric nanoparticles to enhance sonodynamic immunotherapy

open access: yesBMEMat, EarlyView.
Leveraging bacterial hypoxia targeting, KBTO NPs accumulate at the tumor site. Under the ultrasound irradiation, KBTO NPs produce reactive oxygen species to kill tumor cells and eliminate bacteria, preventing overgrowth and inflammation. The lysed bacteria act as antigens to trigger antitumor immunity and further enhanced by the immune checkpoint ...
Chongyang Liu   +12 more
wiley   +1 more source

Microfluidic Paper-based Devices For Bioanalytical Applications.

open access: yes, 2015
Paper has become increasingly recognized as a very interesting substrate for the construction of microfluidic devices, with potential application in a variety of areas, including health diagnosis, environmental monitoring, immunoassays and food safety ...
Nery, Emilia W   +3 more
core   +1 more source

MOAL bioanalysis workflow R package

open access: yes, 2023
<p>MOAL (Multi Omic Analysis at Lab) is an integrated bioanalysis workflow requiring normalized data matrix as input, and automatically providing statistical and functional enrichment results.</p ...
Bernadat, Guillaume, Dumont, Florent
core   +1 more source

Surface-Enhanced Raman Scattering (SERS) With Silver Nano Substrates Synthesized by Microwave for Rapid Detection of Foodborne Pathogens

open access: yesFrontiers in Microbiology, 2018
Rapid and sensitive methods have been developed to detect foodborne pathogens, a development that is important for food safety. The aim of this study is to explore Surface-enhanced Raman scattering (SERS) with silver nano substrates to detect and ...
Caijiao Wei, Mei Li, Xihong Zhao
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries   +8 more
wiley   +1 more source

Bioanalysis An Important Tool in Drug Discovery

open access: yes, 2018
In past, the major reason causing new drug failure was the lack of proper analysis of pharmacokinetic data due to absence of any high advanced techniques but recent years witnessed various advancement in the field of analytical techniques and one of ...
Ashutosh Badola   +2 more
core   +1 more source

Localized 3D acoustic streaming in microdroplets using high‐frequency micro‐beam IDTs

open access: yesDroplet, EarlyView.
Miniaturized 160 MHz acoustic microbeam transducers, with a size much smaller than droplets, enable precise localized actuation, generating complex three‐dimensional streaming and tunable particle aggregation. This concept provides high‐resolution, non‐contact fluid manipulation for biosensing, lab‐on‐chip diagnostics, and targeted drug screening ...
D. Sánchez‐Saldaña   +2 more
wiley   +1 more source

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

open access: yesmAbs, 2020
Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery.
Zhiqiang Chen   +7 more
doaj   +1 more source

Conference Report: 5th Bioanalysis in Clinical Research

open access: yes, 2010
The 5th Annual Bioanalysis in Clinical Research recently held in London, UK, covered a broad spectrum of interesting topics within bioanalytical method validation (BMV) including perspectives from the US FDA and European Medicines Agency (EMA) and ...
Michael Zhou
core   +1 more source

Body‐integrated photonic biosensors: Illuminating the path to active healthcare

open access: yesFlexMat, EarlyView.
Body‐integrated photonic biosensors are promising tools for active healthcare. These optical devices can be worn, implanted, or swallowed to monitor health signals continuously. This review introduces key sensing modalities, including fluorescence, colorimetry, SPR, LSPR, SERS, and light‐modulating materials.
Jiayue Gu   +10 more
wiley   +1 more source

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