Results 211 to 220 of about 296,429 (339)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Contact exposure to ivermectin induces acute mortality and inhibits parasite development in malaria vectors. [PDF]

Sci Rep
Jeena M, Goyal B, Lata S, Kumar G, Pradhan LK, Thakur Y, Kaur G, Verma V, Pandey KC, Pasi S, Kaur J.   +10 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Quantitative and Comparative Assessment of Recombinant Human β-Glucocerebrosidase Uptake Bioactivity Using a Stable hMMR-Expressing CHO Cell Model. [PDF]

Molecules
Wang L, Xu K, Lyu P, Hu X, Li J.
europepmc   +1 more source

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, EarlyView.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

Bioassay of the infectivity of heat-treated <i>Toxoplasma gondii</i> cysts in susceptible C57BL/6J mice. [PDF]

Food Waterborne Parasitol
Li Z, Li T, Yang LT, Deng CQ, Liu QX, Qin-Zhang, Wu L, Sun Y, Zou FC, Zhou X, Liu QS.   +10 more
europepmc   +1 more source

Correlation between bioassayed plasma levels of FK 506 and lymphocyte growth from liver transplant biopsies with histological evidence of rejection. [PDF]

, 1991
Abu-Elmagd, K, Alessiani, M, Burckart, G, Demetris, AJ, Eiras, G, Jain, A, Kaufman, C, Venkataramanan, R, Warty, V, Zeevi, A   +9 more
core  

Analytical performance and clinical utility of a bioassay for thyroid-stimulating immunoglobulins.

American Journal of Clinical Pathology, 2013
Johannes J Leschik, T. Diana, P. D. Olivo, J. König, U. Krahn, Yunsheng Li, M. Kanitz, G. Kahaly   +7 more
semanticscholar   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

RNAi spray-induced gene silencing of <i>EPSPS</i> by topical application of dsRNA in the weed <i>Digitaria insularis</i>. [PDF]

Front Plant Sci
Cintra LA, Da Rosa J, De Assis R, Marin SRR, Adegas FS, Rech EL, Nepomuceno AL, Mertz-Henning LM.   +7 more
europepmc   +1 more source