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Quantitative Single-Molecule Electrochemiluminescence Bioassay.
Angewandte Chemie, 2022A single-molecule electrochemiluminescence bioassay is developed here which allows imaging and direct quantification of single biomolecules. Imaging single biomolecules is realized by localizing the electrochemiluminescence events of the labeled ...
Wenxin Zhu +4 more
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Controlled Clinical Trials, 1984
Linear multivariate theory is applied to \textit{A. Vølund}'s [ibid. 36, 225-236 (1980; Zbl 0436.62092)] multivariate bioassay problems resulting in more powerful tests of hypotheses, a simple ML estimator of relative potency, and a Fieller-like confidence interval.
Eugene M. Laska +3 more
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Linear multivariate theory is applied to \textit{A. Vølund}'s [ibid. 36, 225-236 (1980; Zbl 0436.62092)] multivariate bioassay problems resulting in more powerful tests of hypotheses, a simple ML estimator of relative potency, and a Fieller-like confidence interval.
Eugene M. Laska +3 more
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Combining Multivariate Bioassays
Biometrics, 1986Linear multivariate theory is applied to the problem of combining several multivariate bioassays. Results are an asymptotic test of the hypothesis of a common log relative potency; the maximum likelihood estimator of the common log relative potency; and an exact and asymptotic confidence interval estimator for log relative potency.
Meisner, Morris +2 more
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Methods, 2000
Bioassays constitute a unique approach to determine the functional aspects of gonadotropins. Indeed, these highly complex glycoprotein hormones, including pituitary lutropin (LH) and follitropin (FSH), are heterogeneous in terms of both peptidic and carbohydrate moieties, and, as a consequence, the bioactivity of the different molecular forms often ...
Christin-Maitre, S +3 more
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Bioassays constitute a unique approach to determine the functional aspects of gonadotropins. Indeed, these highly complex glycoprotein hormones, including pituitary lutropin (LH) and follitropin (FSH), are heterogeneous in terms of both peptidic and carbohydrate moieties, and, as a consequence, the bioactivity of the different molecular forms often ...
Christin-Maitre, S +3 more
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Biometrics, 1980
In a multivariate bioassay the response variable is r-dimensional and the dose variable is one-dimensional. Thus, the graph of the dose response relation is a curve in the (r+1)-dimensional space. The similarity requirement for a test and a standard is divided into two parts: (i) a condition of marginal similarity corresponding to the usual similarity ...
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In a multivariate bioassay the response variable is r-dimensional and the dose variable is one-dimensional. Thus, the graph of the dose response relation is a curve in the (r+1)-dimensional space. The similarity requirement for a test and a standard is divided into two parts: (i) a condition of marginal similarity corresponding to the usual similarity ...
openaire +2 more sources
2003
Cytokines are important mediators in inflammation, and play a key role in inflammation induced by Gram-negative bacteria. Cytokines are released into serum during different pathological conditions, such as meningococcal disease, and the cytokine levels in serum seem to correlate with fatal outcome of septic shock (1-3).
N B, Liabakk +4 more
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Cytokines are important mediators in inflammation, and play a key role in inflammation induced by Gram-negative bacteria. Cytokines are released into serum during different pathological conditions, such as meningococcal disease, and the cytokine levels in serum seem to correlate with fatal outcome of septic shock (1-3).
N B, Liabakk +4 more
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Cold Spring Harbor Protocols, 2023
Insecticide bioassays are frequently used to measure levels of insecticide resistance in mosquito populations, examining the ability of mosquitoes to survive exposure to insecticides. Laboratory bioassays measure insects’ responses to insecticides in resistant (field) populations and laboratory susceptible strains using serial doses or concentrations ...
Yifan, Wang, Ting, Li, Nannan, Liu
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Insecticide bioassays are frequently used to measure levels of insecticide resistance in mosquito populations, examining the ability of mosquitoes to survive exposure to insecticides. Laboratory bioassays measure insects’ responses to insecticides in resistant (field) populations and laboratory susceptible strains using serial doses or concentrations ...
Yifan, Wang, Ting, Li, Nannan, Liu
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Validation of in-vitro bioassay methods: Application in herbal drug research.
Profiles of Drug Substances, Excipients and Related Methodology, 2021G. Indrayanto +2 more
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Multivariate Bioassay, Combination of Bioassays, and Fieller's Theorem
Biometrics, 1986In this paper alternative methods for estimating the relative potency, its confidence intervals, and testing for proportionality are developed for multivariate bioassays. The test and estimate are based on the smaller characteristic root and the corresponding characteristic vector of a 2 X 2 matrix.
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