Results 101 to 110 of about 385,548 (309)

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Computer-augmented modeling studies of Pb(II) and Cd(II) complexes with maleic acid in ethylene glycol–water mixture

Chemical Speciation & Bioavailability, 2016
Chemical speciation of binary complexes of Pb(II) and Cd(II) ions with maleic acid have been studied pH metrically in the concentration range of 0–50% v/v ethylene glycol (EG)–water mixtures maintaining an ionic strength of 0.16 molL−1 at 303 K ...
Ch. Nageswara Rao, Bogi Srinu, V. Gowri Kumari, B. B. V. Sailaja   +3 more
doaj   +1 more source

Genetic programming in data mining for drug discovery

, 2004
Genetic programming (GP) is used to extract from rat oral bioavailability (OB) measurements simple, interpretable and predictive QSAR models which both generalise to rats and to marketed drugs in humans. Receiver Operating Characteristics (ROC) curves
Barrett, S.J., Langdon, W.B.
core  

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

The Bioavailabillity of Beta-Carotene in Stir- or Deep-Fried Vegetables in Men Determined by Measuring the Serum Response to a Single Ingestion

, 2008
To evaluate the bioavailability of beta-carotene from plant foods, the serum beta-carotene response to a single ingestion of various beta- carotene sources was determined in 10 healthy men.
黃青真;陳慶餘, HUANG, CHING-JANG;CHEN, CHING-YU   +1 more
core  

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Co-transport of Pb (II) and Cd (II) in saturated porous media: effects of colloids, flow rate and grain size

Chemical Speciation & Bioavailability, 2018
The transport of Pb(II) or Cd(II) in subsurface has been studied in the literature; however; their co-transport in porous media in presence of colloids has not been clearly understood.
Bingyi Xie, Yanji Jiang, Zhe Zhang, Gang Cao, Huimin Sun, Nong Wang, Shengsen Wang   +6 more
doaj   +1 more source

Beta-lactoglobulin Complexed Vitamins A and D in Skim Milk: Shelf Life and Bioavailability

, 2003
As reduced fat dairy products became popular in the U.S., the reduction of vitamins A and D in these products rendered a nutritional concern. Beta-lactoglobulin has been reported capable of binding fat-soluble vitamins. In order to justify the potential
Liu, Ying
core  

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Efficient adsorptive removal of Congo red from aqueous solution by synthesized zeolitic imidazolate framework-8

Chemical Speciation & Bioavailability, 2016
Dyes exposure in aquatic environment creates risks to human health and biota due to their intrinsic toxic mutagenic and carcinogenic characteristics.
Canlan Jiang, Boming Fu, Hao Cai, Tianming Cai   +3 more
doaj   +1 more source