Results 121 to 130 of about 385,548 (309)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Arsenic Bioavailability Assessment - Former Pipfruit Orchards on Mapua and Ranzau Soils, Tasman District (Massey University and Tasman District Council)

, 2016
Tasman District Council (TDC) commissioned Massey University to investigate oral bioavailability of arsenic at former orchard sites selected by TDC, and prepare a ‘Tier II’ health risk assessment for sampled soil types. Massey, in turn, commissioned HAIL
Lines W, Bull D
core  

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Urinary Pharmacokinetic Methodology to Determine the Relative Lung Bioavailability of Inhaled Beclometasone

Urinary pharmacokinetic methods have been introduced to identify the relative lung and systemic availability of inhaled drugs but have not been extended to corticosteroids.
Said, Amira
core  

Developing site-specific guidelines for orchard soils based on bioaccessibility – Can it be done?

, 2008
Horticultural land within the periurban fringe of NZ towns and cities increasingly is being developed for residential subdivision. Recent surveys have shown that concentrations of As, Cd, Cu, Pb, and ΣDDT (sum of DDT and its degradation products DDE and ...
Kim, Nicholas D., Northcott, Grant, Wilkins, Alistair L., Gaw, Sally K., Robinson, Gavin   +4 more
core  

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

, 2015
Jin-Yang Shen,1,* Xiao-Lin Yang,2,* Zhong-Lin Yang,1 Jun-Ping Kou,1 Fei Li11State Key Laboratory of Natural Medicines, China Pharmaceutical University, 2Key Laboratory of Pharmaceutical and Biological Marine Resources Research and Development of Jiangsu ...
Li F, Kou JP, Yang XL, Shen JY, Yang ZL
core  

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Niosomal carriers enhance oral bioavailability of carvedilol: effects of bile salt-enriched vesicles and carrier surface charge 

, 2015
Gelareh Arzani,1 Azadeh Haeri,1 Marjan Daeihamed,1 Hamid Bakhtiari-Kaboutaraki,1 Simin Dadashzadeh1,2 1Department of Pharmaceutics, Faculty of Pharmacy, 2Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran ...
Bakhtiari-Kaboutaraki H, Daeihamed M, Arzani G, Dadashzadeh S, Haeri A   +4 more
core  

Arsenic in hydrological processes-Sources, speciation, bioavailability and management

, 2014
This Special Issue of Journal of Hydrology, 'Arsenic in hydrological processes—sources, speciation, bioavailability and management' includes scientific contributions which offer 'state of the art' knowledge about the sources and dynamics of As in ...
Bundschuh, J., Bhattacharya, Prosun, Bundschuh, Jochen, Bhattacharya, P., Charlet, L., Polya, David A., Charlet, Laurent, Naidu, R., Polya, D., Bhattacharya, Prosun,, Polya, David A; id_orcid, Mukherjee, Abhijit, Naidu, Ravi   +12 more
core   +1 more source