Results 121 to 130 of about 719,874 (416)

Systems biological approach of molecular descriptors connectivity: optimal descriptors for oral bioavailability prediction. [PDF]

PLoS ONE, 2012
Poor oral bioavailability is an important parameter accounting for the failure of the drug candidates. Approximately, 50% of developing drugs fail because of unfavorable oral bioavailability.
Shiek S S J Ahmed, V Ramakrishnan
doaj   +1 more source

Theoretical construction of thermodynamic relations for a solvent-controlled phase transition to improve the bioavailability of drugs: A case study of indomethacin [PDF]

arXiv, 2018
The thermodynamic aspects of the polymorphic phase transition from {\alpha}-indomethacin to {\gamma}-indomethacin are the fundamental key to find the most bioavailable phase of indomethacin. In the present work, varying the temperature and solvent permittivity changes the polymorphic transitions.
arxiv  

The influence of liver dysfunction on cyclosporine pharmacokinetics -A comparison between 70 per cent hepatectomy and complete bile duct ligation in dogs- [PDF]

, 1989
The influence of experimentally induced hepatic dysfunction on the pharmacokinetics of Cyclosporine A (CsA) was determined in dogs. The pharmacokinetics of oral (PO) and intravenous (IV) CsA were studied before and after 70 per cent hepatectomy or ...
B Sigel, BD Kahan, F Barbier, F Follath, G Burckart, G Paumgartner, GC Yee, GR Cherrick, Hisaaki Koie, I Sendama, Iman Zaghloul, JB Price, JM Hows, LF Rikkers, M Teranaka, R Mizumoto, R Venkataramanan, Raman Venkataramanan, RG Buice, RJ Sawchuk, Shunichi Takaya, Shunzaburo Iwatsuki, Takashi Noguchi, TE Starzl, Thomas E. Starzl   +24 more
core   +1 more source

Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits

Frontiers in Nutrition, 2020
In order to fully exploit the nutrient density concept, thorough understanding of the biological activity of single nutrients in their interaction with other nutrients and food components from whole foods is important.
A. Melse‐Boonstra
semanticscholar   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Diversity and distribution of nirS-type denitrifiers as a biological indicator in response to environmental gradients in the eutrophied Haizhou Bay, China

Environmental Pollutants & Bioavailability, 2019
Denitrifying bacterial communities play an important role in nitrogen removal. The diversity, abundance and distribution of denitrifiers can be applied in eutrophication assessment for the bay ecosystems.
Chunyan Wang, Jianyang Song, Xiaoling Hu, Yumei Zhang, Hongyu Wang, Lixin Li   +5 more
doaj   +1 more source

Cadmium in newborns [PDF]

, 2003
Cadmium (Cd) is a well-known nephrotoxic environmental contaminant but there are indications that the developing nervous system might be even more sensitive to Cd than the kidneys in adults.
Eklund, Gunilla
core  

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling

Scientific Reports
The study is based on applying Artificial Neural Network (ANN) based machine learning and Response Surface Methodology (RSM) as simultaneous bivariate approaches in developing controlled-release rivaroxaban (RVX) osmotic tablets.
Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui   +3 more
doaj   +1 more source

Changes in phosphorus fractions caused by increased microbial activity in forest soil in a short-term incubation study

Chemical Speciation & Bioavailability, 2018
The effects of adding larch (Larix kaempferi) leaf litter and nitrogen (N) on microbial activity and phosphorus (P) fractions in forest soil were examined in a short-term (28-d) laboratory incubation study.
Takashi Kunito, Naomi Hiruta, Yasunori Miyagishi, Hirotaka Sumi, Hitoshi Moro   +4 more
doaj   +1 more source