Results 231 to 240 of about 719,874 (416)
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization
Advanced Science, EarlyView.This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan +12 more
wiley +1 more source
Elemental models of primate nursing and weaning revisited
American Journal of Biological Anthropology, Volume 180, Issue 1, Page 216-223, January 2023., 2023 Abstract Objectives Intra‐tooth patterns of trace elements barium (Ba) and strontium (Sr) have been used to infer human and nonhuman primate nursing histories, including australopithecine and Neanderthal juveniles. Here, we contrast the two elemental models in first molars (M1s) of four wild baboons and explore the assumptions that underlie each ...
Tanya M. Smith +4 more
wiley +1 more source
Advanced Science, EarlyView.These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma +12 more
wiley +1 more source
Regulatory effect of gut microbes on blood pressure
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022 The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan +6 more
wiley +1 more source
Bioavailability Of Phosphorus And Its Effect On The Nutrient Utilization In Cattle
, 1970 MA Rahman +2 more
openalex +2 more sources
Bioavailability assessment of topical delivery systems: Effect of vehicle evaporation upon in vitro delivery of minoxidil from solution formulations [PDF]
, 1989 Chiang Chia-Ming +3 more
openalex +1 more source
Bioavailability and effects of microplastics on marine zooplankton: A review.
Environmental Pollution, 2019 Zara L. R. Botterell +5 more
semanticscholar +1 more source
Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration
Advanced Science, EarlyView.This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong +17 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 557-564, December 2022., 2022 In the current study, after anesthetized rat with urethan the femoral artery was cannulated, then its head was mounted on a stereotaxic instrument and drugs (saline‐NAME, L‐Arg, and L_Arg+ L‐NAME) microinjected into the dmPAG and cardiovascular responses that recorded by a Power lab were evaluated.
Mohammad Najaftomaraei +5 more
wiley +1 more source