Results 271 to 280 of about 803,201 (379)

The Antagonistic Influence of Phytic Acid on Zinc Absorption: An <i>In Vitro</i> Comparison of Inorganic and Chelated Trace Mineral Sources. [PDF]

Nutrients
Rock N, Clynes M, Horgan K, Murphy R, O'Sullivan F, Keenan J.   +5 more
europepmc   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Dermal Concentration Versus Systemic Bioavailability of Topical Lidocaine and Tetracaine: An Exploratory Pharmacokinetic Pilot Study in Göttingen Minipigs. [PDF]

Pharmaceutics
Biernat P, Bursy D, Marciniak D, Krajewski K, Meler J, Balwierz R.   +5 more
europepmc   +1 more source

Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors

, 2016
Cheng Dai, Jun Liu, Dong Han, Guobao Zhang, Wenqi Gao, Mindy H. Hsieh, Nicholas Ng, Shailaja Kasibhatla, Celin Tompkins, Jie Li, Auzon Steffy, Fangxian Sun, Chun Li, H. Martin Seidel, Jennifer L. Harris, Shifeng Pan   +15 more
openalex   +1 more source

Asparagine bioavailability governs metastasis in a model of breast cancer

Nature, 2018
S. Knott, S. Knott, S. Knott, Elvin Wagenblast, Elvin Wagenblast, Elvin Wagenblast, Showkhin Khan, S. Y. Kim, Mar Soto, M. Wagner, Marc-Olivier Turgeon, L. Fish, Nicolas Erard, Annika L. Gable, Ashley R. Maceli, Steffen Dickopf, Evangelia K. Papachristou, C. D’Santos, L. Carey, J. Wilkinson, J. Harrell, C. Perou, H. Goodarzi, G. Poulogiannis, G. Hannon, G. Hannon   +25 more
semanticscholar   +1 more source

MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection

Advanced Science, EarlyView.
MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani, Luca Capelli, Denise Di Lena, Alejandro Chamorro‐Garcia, Rudy Ippodrino, Alessandro Porchetta, Alessandro Bertucci   +6 more
wiley   +1 more source

Silymarin and Silybin: Rejuvenating Traditional Remedies with Modern Delivery Strategies. [PDF]

Pharmaceutics
Li X, Zhu H, Wang Y, Zhang X, Yang Z, Yan X, Yu Q.   +6 more
europepmc   +1 more source

Influence of soil ageing on bioavailability and ecotoxicity of lead carried by process waste metallic ultrafine particles

, 2011
Eva Schreck, Yann Foucault, Florence Géret, Philippe Pradère, Camille Dumat   +4 more
openalex   +2 more sources

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Spray Drying for Pharmaceutical Raw Materials: A Systematic Review on Enhancing Bioavailability and Stability. [PDF]

Drug Des Devel Ther
Swm AM, Mita SR, Husni P.
europepmc   +1 more source