Results 151 to 160 of about 171,678 (355)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Journal of Epidemiology, 2018
Background: The Genome Database of the Latvian Population (LGDB) is a national biobank that collects, maintains, and processes health information, data, and biospecimens collected from representatives of the Latvian population. These specimens serve as a
Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins   +5 more
doaj   +1 more source

Comparison of phenomic profiles in the All of Us Research Program against the US general population and the UK Biobank

J. Am. Medical Informatics Assoc.
IMPORTANCE Knowledge gained from cohort studies has dramatically advanced both public and precision health. The All of Us Research Program seeks to enroll 1 million diverse participants who share multiple sources of data, providing unique opportunities ...
Chenjie Zeng, David J. Schlueter, Tam C. Tran, Anav Babbar, T. Cassini, L. Bastarache, Joshua C. Denny   +6 more
semanticscholar   +1 more source

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.

Cell, 2019
Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development of effective therapeutic strategies. Current in vitro models are limited in preserving the cellular and mutational diversity of parental tumors and require a ...
Fadi Jacob, Fadi Jacob, Ryan D. Salinas, Daniel Y. Zhang, Phuong T T Nguyen, Jordan G. Schnoll, S. Wong, S. Wong, R. Thokala, S. Sheikh, Deeksha Saxena, S. Prokop, Di Liu, Xuyu Qian, Xuyu Qian, D. Petrov, T. Lucas, H. I. Chen, J. Dorsey, K. Christian, Zev A. Binder, M. Nasrallah, S. Brem, D. O’Rourke, G. Ming, Hongjun Song   +25 more
semanticscholar   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants

Lancet Public Health, 2018
Summary Background Frailty is associated with older age and multimorbidity (two or more long-term conditions); however, little is known about its prevalence or effects on mortality in younger populations.
P. Hanlon, B. Nicholl, B. Jani, Duncan Lee, R. McQueenie, F. Mair   +5 more
semanticscholar   +1 more source

Biobank participants' involvement in activities of the biobank.

, 2019
Biobank participants' involvement in activities of the biobank.
Martin Boeckhout (7400720), Lars Ursin (7400708), Liis Leitsalu (3686728), Gillian Martin (6451223), Anna Durnová (7400711), Marialuisa Lavitrano (485800), Sara Casati (7400717), Michaela Th. Mayrhofer (7400723), Melanie Goisauf (7400699), Deborah Mascalzoni (76505), Isabelle Budin-Ljøsne (7400705), Heidi Beate Bentzen (7400702), Katharine Smith (7400714)   +12 more
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Jordanians’ Perspectives On Open Consent In Biomedical Research

Risk Management and Healthcare Policy, 2019
Nasr Alrabadi,1 Hanin Makhlouf,2 Omar F Khabour,2 Karem H Alzoubi3 1Department of Pharmacology, Faculty Of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Medical Laboratory Sciences, Faculty of Medical Sciences ...
Alrabadi N, Makhlouf H, Khabour OF, Alzoubi KH   +3 more
doaj  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source