Results 161 to 170 of about 171,678 (355)

Genetic and Phenotypic Features of Schizophrenia in the UK Biobank

JAMA psychiatry
Key Points Question How do individuals with a diagnosis of schizophrenia recruited in a large volunteer-based research resource (UK Biobank) differ from those in the Psychiatric Genomics Consortium (PGC) or those recruited from clinical settings ...
S. Legge, A. Pardiñas, Grace Woolway, E. Rees, A. Cardno, V. Escott-Price, P. Holmans, G. Kirov, Michael J. Owen, M. O’Donovan, James T. R. Walters   +10 more
semanticscholar   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)

, 2012
Henry Christensen,1 Jens Steen Nielsen,2 Karina Meden Sørensen,3 Mads Melbye,3 Ivan Brandslund1,41Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark; 2The Danish Centre for Strategic Research in Type 2 Diabetes (DD2 ...
Brandslund I, Nielsen JS, Christensen H, Sorensen KM, Melbye M   +4 more
core  

Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants

Efficient use of genetic biobank data in support of clinical care would enhance the adoption of personalized medicine. Identification of carriers of medically actionable variants that predispose to cancer enables intensified screening and follow-up to ...
Ala-Kulju, Kimmo, Carpén, Olli, Lappalainen, Maarit, Pehrsson, Minja   +3 more
core   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

Under-estimated burden of pertussis among middle and older-aged adults: A longitudinal seroepidemiological study in Taiwan during 2014–2020

Journal of Infection and Public Health
Background: The resurgence of pertussis has been observed in Taiwan in the last 2 decades. Most cases are infants and young children, and few were reported in adults.
Ming-Han Tsai, Chih-Jung Chen, Lan-Yan Yang, Yu-Bin Pan, Hsiang-Ju Shih, Chyi-Liang Chen, Cheng-Hsun Chiu   +6 more
doaj   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Building a foundation to promote Women’s health research in Dubai. Study protocol for a project to investigate the feasibility of establishing a dedicated Women’s health biobank

Frontiers in Global Women's Health
Women’s health concerns play a role in several of the UAE's major public health challenges, including cardiovascular disease, injuries, cancer, and respiratory conditions.
William Atiomo, Fadi Mirza, Fadi Mirza, Khawla Al Zarooni, Muna Tahlak, Muna Tahlak, Tom Loney, Asiyah Shafi, Osman Zin Al Abdin, Mahmood Al Mashhadani, Samuel Ho, Arnaud Wattiez, Manal AbdulRahim, Mutairu Ezimokhai   +13 more
doaj   +1 more source