Results 181 to 190 of about 191,359 (300)

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Advancing Life Sciences and Biotechnology in Saudi Arabia: A Comprehensive Overview of the Saudi Biobank Project Study Design and Aspirations. [PDF]

J Epidemiol Glob Health
Badreldin HA, Alnasser LA, Alfadhel M, Bouchama A, Alshareeda AT, Alfaris S, AlKhalaf H, Alhamid A, Saidan TB, Alhendi Y, Alhusainan N, Alnefaie H, Alqahtani H, Alsayed A, Alhamdan M, Albqomi A, Albaijan L, Alanazi M, Almutairi A, Alshehri H, Alhbdan A, Alhussain S, AlMurdhi N, Alzamil S, Alalaq R, Alsaleh K, Almutiri L, Cuevas J, Ahmed S, Alshahrani A, Khan M, Kaithathara S, Almutairi A, Boudjelal M, Alsomaie B, Abolfotouh M, Alaskar A.   +36 more
europepmc   +1 more source

Frailty and Cardiovascular Events as Determined by Body Composition: A Systematic Review

Chronic Diseases and Translational Medicine, EarlyView.
Frailty phenotypes and risk of cardiovascular disease. Sarcopenic obese phenotype is associated with increased prevalence of cardiovascular risk factors and progression of metabolic syndrome, leading to cardiovascular events and cardiovascular mortality, while the Anorexic malnourished phenotype is associated with reduced prevalence of cardiovascular ...
Ishleen Oberoi, Shabnam Tariq, Kristian Arak, Mhd Alaa Aldin Al‐Haffar, Kyaw Thet, Ahmed H. Abdelhafiz   +5 more
wiley   +1 more source

Assessing the causal impact of leisure-time physical activity and screen time on lifespan: a Mendelian randomization study. [PDF]

Eur Rev Aging Phys Act
Jiesisibieke ZL, Schooling CM.
europepmc   +1 more source

Blood donor biobank pipeline to collect genome-based samples for research. [PDF]

Sci Rep
Honkanen J, Timonen VA, Koski JR, Juvila J, Arvas M, Blood Service Biobank, FinnGen, Hartwall L, Kilpivaara O, Rodosthenous RS, Wartiovaara-Kautto U, Vuorela A, Daly M, Palotie A, Pitkänen E, Partanen J.   +15 more
europepmc   +1 more source

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source

Associations of oxidative balance score with mortality and cardiovascular events: cohort study from NHANES and UK Biobank. [PDF]

BMJ Open
Zhang H, Chen S, Bai X, Zhou X, Zhang F, Wang X, Chen L, Wang X.   +7 more
europepmc   +1 more source

Tracheal wash culture is not associated with bronchial infection, remodelling or inflammation in horses with asthma

Equine Veterinary Journal, EarlyView.
Abstract Background Antimicrobials are commonly prescribed for the treatment of equine asthma, despite limited evidence supporting their use. Tracheal wash (TW) bacterial culture results are known to influence antimicrobial prescription decisions. Objectives To determine whether a positive TW bacterial culture in horses with asthma is associated with ...
Laurence Leduc, Guillaume St‐Jean, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

Parkinson's disease dementia and hearing impairment, are they related? A UK biobank pilot analysis. [PDF]

Exp Brain Res
Readman MR, Giebel C, Cannon J, Fairman I, Plack CJ.   +4 more
europepmc   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source