Results 201 to 210 of about 147,982 (310)

Serum insulin-like growth factor-1 and its association with epilepsy risk and cognitive function. [PDF]

Acta Epileptol
Guo J, Qiu Z, Chen B, Li H, Su P, Yuan Z, Wu D, Fang J.   +7 more
europepmc   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis. [PDF]

Int J Behav Nutr Phys Act
Stein MJ, Lendt C, Bamberg F, Barbaresko J, Baurecht H, Berger K, Bohmann P, Brummer J, Buck C, Fischer B, Freisling H, Georges D, Greiser KH, Heise JK, Herbolsheimer F, Huemer MT, Karch A, Keil T, Krist L, Lieb W, Meinke-Franze C, Mikolajczyk R, Nimptsch K, Obi N, Övermöhle C, Pischon T, Ringhof S, Schmidt B, Scholz M, Sekula P, Steindorf K, Stürmer P, Völzke H, Westerman R, Wirkner K, Wirler J, Peters A, Leitzmann MF.   +37 more
europepmc   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

The central biobank and virtual biobank of BIOMARKAPD

Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's ...
Reijs, Babette L. R., Teunissen, Charlotte E.||, Goncharenko, Nikolai||, Betsou, Fay||, Blennow, Kaj||, Baldeiras, Inês||, Brosseron, Frederic, Cavedo, Enrica||, Fladby, Tormod||, Froelich, Lutz||, Gabryelewicz, Tomasz, Gurvit, Hakan||, Kapaki, Elisabeth N., Koson, Peter, Kulic, Luka, Lehmann, Sylvain||, Lewczuk, Piotr||, Lleó, Alberto||, Maetzler, Walter||, de Mendonça, Alexandre||, Miller, Anne-Marie, Molinuevo, José Luis||, Mollenhauer, Brit||, Parnetti, Lucilla||, Rot, Uroš, Schneider, Anja||, Simonsen, Anja Hviid||, Tagliavini, Fabrizio||, Tsolaki, Magda||, Verbeek, Marcel||, Verhey, Frans, Zboch, Marzena, Winblad, Bengt||, Scheltens, Philip||, Zetterberg, Henrik||, Visser, Pieter Jelle||   +35 more
openaire   +1 more source

Integrative prediction of Alzheimer's disease and related dementias using multi-omics aging clocks and genetic data. [PDF]

Alzheimers Dement
Mostafaei S, Gustavsson K, Hagelin H, Mak JKL, Vu TN, Karlsson IK, Hägg S.   +6 more
europepmc   +1 more source

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Development and external validation of a metabolic and lipid-based model for predicting subsequent pregnancy in women with endometriosis. [PDF]

Front Immunol
Duan Y, Chen A, Yao Y.
europepmc   +1 more source

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Dihydropyrimidine Dehydrogenase Genotype–Phenotype Correlations in Plasma and Peripheral Blood Mononuclear Cells

Clinical Pharmacology &Therapeutics, EarlyView.
The chemotherapeutic 5‐fluorouracil (5‐FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5‐FU toxicity.
Brianna M. Bembenek, Seid Hamzic, Kelly J. Bouchonville, Carlo R. Largiadèr, Steven M. Offer   +4 more
wiley   +1 more source