Results 171 to 180 of about 26,930 (292)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

SCANDARE: an institutional dynamic prospective interventional biobanking study. [PDF]

BMC Cancer
Lamy C, Laurent L, Choussy O, Pouget N, Lecuru F, Reyal F, Plissonnier AS, Kadi A, Berger F, Martin J, Dubray-Vautrin A, Marret G, Borcoman E, Romano E, Sablin MP, Cabel L, Pasquesoone C, Lantz O, Louis D, Gorret D, Da Silva ID, Mariani O, Delattre O, Bièche I, Servant N, Rodrigues M, Pierga JY, Seban RD, Marangoni E, Morillon A, Théry C, Proudhon C, Piaggio E, Vallot C, Mechta-Grigoriou F, Flavius J, Dupain C, Gentric G, Vincent-Salomon A, Kamal M, Le Tourneau C.   +40 more
europepmc   +1 more source

High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective SOD1 is the second most frequently mutated gene in European patients with amyotrophic lateral sclerosis (ALS). Given the recent authorization of SOD1‐targeted antisense oligonucleotides for SOD1‐ALS, prompt screening for SOD1 mutations in patients with ALS patients is highly recommended.
Delia Gagliardi, Chiara Villella, Matteo Zanovello, Virginia Iacobelli, Stefania Corti, Giacomo Pietro Comi, Pietro Fratta, Henry Houlden, Arianna Tucci, Dario Ronchi   +9 more
wiley   +1 more source

Navigating tensions between scientific advancement and ethical practice in biobanking: a qualitative study in Japan. [PDF]

Front Genet
Oikawa M, Takimoto Y.
europepmc   +1 more source

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

Biobanking knowledge and donation willingness among musculoskeletal patients in England: a multisite cross-sectional study. [PDF]

BMJ Open
Boakye Serebour T, Kerasidou A, Gray N, Griffin XL, Peach C, Singh HP, Wheway K, Ambrosio MDG, Baldwin M, Snelling SJB.   +9 more
europepmc   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Streamlining protocols for the establishment of a physical biobank of respiratory viruses in the Philippines. [PDF]

J Transl Med
Reyes-Haygood SJ, Rala-Ramos L, Balgos Pada-On JE, Pigao EC, Nicole Perreras MA, Tongol AF, Leon A, Alonzo-Dimamay MT.   +7 more
europepmc   +1 more source

A Phase 2 Trial of Hydroxychloroquine in Individuals at Risk for Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Individuals with serum elevations of anti–cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA in such at‐risk individuals.
Kevin D. Deane, Christopher C. Striebich, Marie L. Feser, James R. O'Dell, Judith A. James, Jeffrey A. Sparks, John M. Davis III, Jonathan Graf, Maureen A. McMahon, Elizabeth B. Solow, Lindsy J. Forbess, Athan Tiliakos, Elena Schiopu, Maria I. Danila, Diane L. Horowitz, Jonathan Kay, Colin D. Strickland, Joel M. Guthridge, Cristina Arriens, Jennifer M. Grossman, M. Kristen Demoruelle, Elizabeth A. Bemis, Ashley Frazer‐Abel, Chelsie L. Fleischer, David A. Fox, Ted R. Mikuls, Melissa Greenleaf, Kate York, Sarah Walker, Lynette Keyes‐Elstein, Margie Byron, Janel Fedler, Ellen A. Goldmuntz, V. Michael Holers   +33 more
wiley   +1 more source

Current situation and future prospect of biobank. [PDF]

Cytojournal
Wang R, Han X, Jin L, Wang Z, Sun H, Zhang Y.   +5 more
europepmc   +1 more source