Results 171 to 180 of about 32,321 (308)

A review of the key issues associated with the commercialization of biobanks [PDF]

, 2014
Becker, Allan, Borry, Pascal, Burgess, Michael, Burningham, Sarah, Calder, Kathryn, Caulfield, Timothy, Critchley, Christine, Edwards, Kelly, Fullerton, Stephanie M, Gottweis, Herbert, Hyde-Lay, Robyn, Illes, Judy, Isasi, Rosario, Joly, Yann, Kato, Kazuto, Kaye, Jane, Knoppers, Bartha, Lynch, John, Master, Zubin, McGuire, Amy, Meslin, Eric, Nicol, Dianne, O'Doherty, Kieran, Ogbogu, Ubaka, Otlowski, Margaret, Pullman, Daryl, Ries, Nola, Scott, Chris, Sears, Malcolm, Shabani, Mahsa, Wallace, Helen, Zawati, Ma'n H   +31 more
core   +2 more sources

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Navigating tensions between scientific advancement and ethical practice in biobanking: a qualitative study in Japan. [PDF]

Front Genet
Oikawa M, Takimoto Y.
europepmc   +1 more source

ANK1 and EPB41 Variants and the Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Leveraging Large and Diverse Biobanks to Evaluate Gene-Disease Associations in Hypertrophic Cardiomyopathy. [PDF]

J Pers Med
Dababneh SF, Ong K, Yeung D, Hawkins NM, Krahn A, Laksman Z, Tadros R, Roston TM.   +7 more
europepmc   +1 more source

Autonomy and Consent in Biobanks [PDF]

, 2010
Schwartz, Peter H.
core  

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, EarlyView.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Phage biobanks as enabling infrastructure for precision phage therapy in the era of antimicrobial resistance. [PDF]

Front Antibiot
Topa-Pila P, Morales KY, Palacios-Mora DP, Flores-Hernández C, Altamirano-Cisneros A, Gavilanes JM, Villacís-López K, Arancibia M, Mora-Domínguez J, Calero-Cáceres W.   +9 more
europepmc   +1 more source

Life sciences and biotechnology – A strategy for Europe. Third progress report and future orientations. Report from the Commission to the European Parliament, the Council and the Economic and Social Committee. COM (2005) 286 final, 29 June 2005 [PDF]

, 2005

core