Results 181 to 190 of about 20,995 (307)

A comprehensive European Colorectal Cancer Cohort dataset. [PDF]

Sci Data
Holub P, Törnwall O, Garcia Alvarez E, Proynova R, Stampe F, Maqsood S, Ataian M, Schlünder I, Carpén O, Meijer G, Nenutil R, Valík D, Parodi B, Hiemstra A, Bierkens M, Castanos-Vélez E, Ückert F, Alexandre D, Vojtíšek O, Bader AL, Simell B, Ahern C, Horvat V, Steinfelder E, Gnocchi M, Moscatelli M, Fürbaß A, Horák J, Frexia F, Mascia C, Sulis A, Delussu G, Del Rio M, Meloni V, Pireddu L, Leo S, Piras ME, Kačenga M, Gofflot S, Mate S, Prokosch HU, Romano P, Pistillo D, Hoffmeister M, Brobeil A, Kugic A, Huppertz B, Paleari V, Müller H, Reihs R, Gemoll T, Bantel Y, Sjöblom T, Kyriacou K, Martino SD, Ciliberto G, Kock-Schoppenhauer AK, Oberländer M, Habermann JK, Husmann G, Edqvist PD, Zlobec I, Berger MD, Boeckmann L, George F, Southerington T, Brucker DP, Faugeras L, Vella J, Felice A, Pace M, Fallerini C, Renieri A, Hadjisavvas A, Sargsyan K, Loizidou MA, Besse-Hammer T, Vogl F, Litton JE, Hummel M, Zatloukal K, Lavitrano M.   +81 more
europepmc   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

A Genome-First Study of Familial Hypercholesterolemia Comparing African and European Ancestry Individuals. [PDF]

Circulation
Winters AH, Kelly MA, Syed MG, Bergquist T, Berry ASF, Mohammed N, Cawley D, Jones LK, Pejaver V, Gidding SS, Oetjens MT.   +10 more
europepmc   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Ethical navigation of biobanking establishment in Ukraine: learning from the experience of developing countries. [PDF]

J Med Ethics
Sulaieva ON, Artamonova O, Dudin O, Semikov R, Urakov D, Zakharash Y, Kacharian A, Strilka V, Mykhalchuk I, Haidamak O, Serdyukova O, Kobyliak N.   +11 more
europepmc   +1 more source

Comparison of Tissue Preparations to Identify and Phenotype T Cells in Human Colorectal Tumor Tissue

Cytometry Part A, EarlyView.
ABSTRACT Archived patient samples (e.g., formalin‐fixed paraffin embedded (FFPE) tissue blocks, cryoembedded tissue blocks, and frozen whole tissue samples) are a source of immune information for which corresponding patient data is often collected.
Justin F. Tirados, Sonya Fenton, Helen M. McGuire, Joanna M. Roberts, Kirsten A. Ward‐Hartstonge, Roslyn A. Kemp   +5 more
wiley   +1 more source

Connecting biospecimens and data: a scoping review-informed conceptual framework for digital infrastructure in biobanking and genomic research in low- and middle-income countries. [PDF]

Front Public Health
Michalska-Falkowska A, Sargsyan K.
europepmc   +1 more source

Gene burden meta‐analysis of 748 879 individuals identifies LGI1‐ADAM23 protein complex association with epilepsy

Epilepsia, EarlyView.
Abstract Epilepsy affects more than 50 million individuals globally and has a substantial genetic component that remains to be completely understood. Traditional studies have focused on severe, early onset cases enrolled through clinical or research settings.
Jessica Castrillon Lal, Costin Leu, Christian M. Boßelmann, Alina Ivaniuk, Eduardo Pérez‐Palma, Dennis Lal   +5 more
wiley   +1 more source

Utilization Patterns of Hospital Biobank Samples: Time to First Use and Material-Specific Demand. [PDF]

J Clin Med
Mucher P, Bayer M, Flieder I, Humer GT, Hou L, Koll A, Radakovics A, Ristic N, Schickbauer T, Müller W, Nguyen VL, Kim-Tran M, Szabo A, Hainfellner JA, Hofer P, Perkmann T, Wagner OF, Haslacher H.   +17 more
europepmc   +1 more source

The central biobank and virtual biobank of BIOMARKAPD

Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's ...
Reijs, Babette L. R., Teunissen, Charlotte E.||, Goncharenko, Nikolai||, Betsou, Fay||, Blennow, Kaj||, Baldeiras, Inês||, Brosseron, Frederic, Cavedo, Enrica||, Fladby, Tormod||, Froelich, Lutz||, Gabryelewicz, Tomasz, Gurvit, Hakan||, Kapaki, Elisabeth N., Koson, Peter, Kulic, Luka, Lehmann, Sylvain||, Lewczuk, Piotr||, Lleó, Alberto||, Maetzler, Walter||, de Mendonça, Alexandre||, Miller, Anne-Marie, Molinuevo, José Luis||, Mollenhauer, Brit||, Parnetti, Lucilla||, Rot, Uroš, Schneider, Anja||, Simonsen, Anja Hviid||, Tagliavini, Fabrizio||, Tsolaki, Magda||, Verbeek, Marcel||, Verhey, Frans, Zboch, Marzena, Winblad, Bengt||, Scheltens, Philip||, Zetterberg, Henrik||, Visser, Pieter Jelle||   +35 more
openaire   +1 more source