Results 181 to 190 of about 31,338 (290)

Biobank participants' perspectives on receiving genetic risk information from a biobank - the case of haemochromatosis. [PDF]

BMC Med Genomics
Clancy J, Forstén J, Koskinen E, Arvas M, Åberg F, Pitkänen K, Castrén J.   +6 more
europepmc   +1 more source

The Promoting Angiogenesis and Its Clinical Significance of CD33+Myeloid Derived Suppressor Cells Derived From Small Cell Lung Cancer

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Myeloid‐derived suppressor cells (MDSCs) are important tumor microenvironment components in small cell lung cancer (SCLC). We successfully identified MDSCs expressing the surface marker CD33 in SCLC; nonetheless, whether CD33+MDSCs promote SCLC angiogenesis remains unclear.
Heran Cui, Jingjing Liu, Peiyan Zhao, Yan Liu, Shaowei Lan, Xueli Jiang, Hui Li   +6 more
wiley   +1 more source

Development of a big data platform for collecting and utilizing clinical information from the Korea Biobank Network. [PDF]

BMC Med Inform Decis Mak
Im YS, Oh SW, Kim KH, Choi W, Choi IY.
europepmc   +1 more source

Biobanking [PDF]

Biomedical Journal of Scientific & Technical Research, 2017
openaire   +1 more source

An Update to the Clinical Pharmacogenetics Implementation Consortium (CPIC) SLCO1B1 Allele Functionality Table Leveraging Evidence from Participants of Predominantly Sub‐Saharan African Ancestry

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) has formally updated the SLCO1B1 allele functionality table based on new evidence. Notably, the alleles studied (SLCO1B1 *9, *31, *41) are enriched in the genomes of patients historically excluded from pharmacogenomics research.
Akinyemi Oni‐Orisan, Sook Wah Yee, Tanushree Haldar, Michelle Whirl‐Carrillo, Kelly Caudle, Deepak Voora, Richard B. Kim   +6 more
wiley   +1 more source

Estimating the use of biological samples in Finnish biobanks and hospital collections. [PDF]

Eur J Hum Genet
Tupasela A, Southerington T, Mäkelä J, Kallio L, Perälä M, Kosma VM, Mannermaa A, Jokela T, Pitkänen K, Kontro M, Vesterinen T, Punkka E, Knopp T, Ruddock M, Serpi R, Moilanen AM, Viiri L, Siltanen S, Makkonen E, Ingalsuo P.   +19 more
europepmc   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Conditional trust as a driver of public engagement in Korea's national project of bio-big data. [PDF]

Front Genet
Kim JS, Kim S, Lee C, Jeong W, No H, Lim S, Jung Y, Lee I, Yang K.   +8 more
europepmc   +1 more source

Biobanks as a Tissue and Information Semicommons: Balancing Interests for Personalized Medicine, Tissue Donors and the Public Health [PDF]

, 2012
Gatter, Ken
core   +2 more sources

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source