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Machine learning applied to biocatalysis research [PDF]
Nature CommunicationsMachine learning (ML) is rapidly influencing the development of many research areas, including biocatalysis, the use of enzymes and living systems to mediate chemical reactions, often of pharmaceutical and industrial importance.
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The CYP152-family P450 enzyme CypC of Bacillus subtilis converts non-natural substrates in plasma-driven biocatalysis [PDF]
Applied Microbiology and BiotechnologyPlasma-driven biocatalysis utilizes in situ H2O2 production by atmospheric pressure plasmas to drive H2O2-dependent enzymatic reactions. Having previously established plasma-driven biocatalysis using recombinant unspecific peroxygenase from Agrocybe ...
Tim Dirks +7 more
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Nature Reviews Methods Primers, 2021 Biocatalysis has become an important aspect of modern organic synthesis, both in academia and across the chemical and pharmaceutical industries. Its success has been largely due to a rapid expansion of the range of chemical reactions accessible, made possible by advanced tools for enzyme discovery coupled with high-throughput laboratory evolution ...
Elizabeth L. Bell +12 more
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Two-Phase Biocatalysis in Microfluidic Droplets
Biosensors, 2021 This Perspective discusses the literature related to two-phase biocatalysis in microfluidic droplets. Enzymes used as catalysts in biocatalysis are generally less stable in organic media than in their native aqueous environments; however, chemical and ...
Lanting Xiang +3 more
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Molecules, 2021 The application of biocatalysis and White Biotechnology tools in chemical areas concerning the production of bulk compounds and other related low-added value products (with high volumes) has been gaining importance in recent years.
Nadia Guajardo +1 more
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Applications of Ionic Liquids in Whole-Cell and Isolated Enzyme Biocatalysis
Molecules, 2021 Ionic liquids have unique chemical properties that have fascinated scientists in many fields. The effects of adding ionic liquids to biocatalysts are many and varied.
Hasan Tanvir Imam +3 more
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New Horizons for Biocatalytic Science
Frontiers in Catalysis, 2022 The use of highly selective enzymes to catalyze value-added reactions outside the cell is commonly termed biocatalysis. In this brief perspective, some of the future opportunities for the application of biocatalysis are discussed.
John M. Woodley
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Microbial Cell Factories, 2021 Background Xylitol is a five-carbon sugar alcohol that has numerous beneficial health properties. It has almost the same sweetness as sucrose but has lower energy value compared to the sucrose.
Tai Man Louie +6 more
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Biocatalysed synthesis planning using data-driven learning
Nature Communications, 2022 As of now, only rule-based systems support retrosynthetic planning using biocatalysis, while initial data-driven approaches are limited to forward predictions.
Daniel Probst +5 more
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Characterization of the novel ene reductase Ppo-Er1 from paenibacillus polymyxa [PDF]
, 2020 Ene reductases enable the asymmetric hydrogenation of activated alkenes allowing the manufacture of valuable chiral products. The enzymes complement existing metal- and organocatalytic approaches for the stereoselective reduction of activated C=C double ...
Aregger, David +2 more
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