Results 141 to 150 of about 3,482,455 (367)

Biochemical Engineering of Cell Surface Sialic Acids Stimulates Axonal Growth [PDF]

, 2002
Bettina Büttner, Christoph Kannicht, Carolin Schmidt, Klemens Löster, Werner Reutter, Hye-Youn Lee, Sabine Nöhring, Rüdiger Horstkorte   +7 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Optimisation of Biochemical Condition and Substrates In Vitro for Tissue Engineering of Ligament [PDF]

, 2006
S. Fawzi‐Grancher, N. de Isla, G Fauré, J.F. Stoltz, S. Müller   +4 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

National Scientific Facilities and Their Science Impact on Non-Biomedical Research

, 2007
H-index, proposed by Hirsch is a good indicator of the impact of a scientist's research. When evaluating departments, institutions or labs, the importance of h-index can be further enhanced when properly calibrated for size.
Kinney, A. L.
core   +2 more sources

The Cytochrome P450 Engineering Database: integration of biochemical properties [PDF]

, 2009
Demet Sirim, Florian Wagner, Andrey Lisitsa, Jürgen Pleiss   +3 more
openalex   +1 more source

Engineering a thixotropic and biochemically tunable hyaluronan and collagen bioink for biofabrication of multiple tissue construct types [PDF]

, 2021
Julio Aleman, Hemamylammal Sivakumar, Thomas J. DePalma, Yu Zhou, Andrea Mazzocchi, Richard Connor Huntwork, KyungMin Yoo, Surya R. Banks, Casey Clark, Alexandra Maycock, Kalan Leaks, Kevin Enck, Emmanuel C. Opara, Paul Gatenholm, Mark E. Welker, Shay Söker, Samuel Herberg, Tracy Criswell, Aleksander Skardal   +18 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Editorial: Asia Pacific Biochemical engineering [PDF]

, 2010
Shūichi Yamamoto, Masahiro Goto, Minoru Seki, Teruyuki Nagamune   +3 more
openalex   +1 more source