Results 41 to 50 of about 4,862,987 (241)

Synthesis of codeine derivative as –a prod rug and study its effect on some biochemical parameters on rabbits [PDF]

Kirkuk Journal of Science, 2015
The codeine was used as carrier of alcohol to attach with non-steroidal anti-inflammatory Drug (aspirin ). The present work is aimed to synthesize the esterification reaction of (OH) group of codeine with aspirin as (acid chloride) which yielded the
Kais A. Nada, Firas s. Abdul-Razzak
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

ASSOCIATION OF ANTHROPOMETRIC AND BIOCHEMICAL PARAMETERS WITH NONALCOHOLIC FATTY LVER DISEASE

Pakistan Armed Forces Medical Journal, 2019
Objective: To study the association of anthropometric and biochemical parameters with nonalcoholic fatty liver disease (NAFLD) diagnosed on ultrasonography (USG). Study Design: Cross sectional analytical study.
Muhammad Usman Munir, Omar Iqbal, Romana Anwar, Juwayria Omar   +3 more
doaj  

Study the effects of naturally acquired canine Dirofil Ariasis on some hematological and biochemical parameters

The Iraqi Journal of Veterinary Medicine, 2017
The present study was aimed to check the amount of variation in some hematologic and biochemical parameters accompanied with natural acquired canine dirofilariasis.
Amal Hassen Atyha
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Bayesian inference of biochemical kinetic parameters using the linear noise approximation [PDF]

, 2009
Background Fluorescent and luminescent gene reporters allow us to dynamically quantify changes in molecular species concentration over time on the single cell level.
David A Rand, Harper, Claire V., Rand David A, Finkenstädt Bärbel, Rand, D. A. (David A.), Finkenstädt, Bärbel, Komorowski, Michał, Michał Komorowski, Harper, Claire V; id_orcid, Harper Claire V, Bärbel Finkenstädt, Komorowski Michał, Komorowski, Michal, Claire V Harper, Rand, David A   +14 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Systems biology: parameter estimation for biochemical models

The FEBS Journal, 2009
Mathematical models of biological processes have various applications: to assist in understanding the functioning of a system, to simulate experiments before actually performing them, to study situations that cannot be dealt with experimentally, etc. Some parameters in the model can be directly obtained from experiments or from the literature.
M. Ashyraliyev (Maksat), Y. Fomekong Nanfack, J.A. Kaandorp (Jaap), J.G. Blom (Joke)   +3 more
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Estudo de parâmetros bioquímicos de éguas gestantes, Puro Sangue Árabe

Brazilian Archives of Biology and Technology, 1999
Em éguas Puro Sangue Árabe manejadas em pastagem de Coast-cross (Cynodon dactylon) foram determinados vários parâmetros bioquímicos no período inicial e final da gestação.
Maria Marina Unanian, Antonio Emidio D. Feliciano Silva, Airton Manzano   +2 more
doaj   +1 more source