Results 51 to 60 of about 4,862,987 (241)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Relevance of the study of metabolic profiles in sheep and goat flock. Present and future: A review
Spanish Journal of Agricultural Research, 2020 Current adoption of technical methods of the production systems and the genetic improvement of flocks’ productivity have led to the emergence of the well-known metabolic diseases or diseases linked to production.
Joaquin Hernandez +2 more
doaj +1 more source
Some blood biochemical parameters of first litter sows in lactation [PDF]
Agroznanje, 2015 The aim of study was to assess metabolic status of sows from intensive production at the beginning and end of lactation by determination of selected biochemical blood parameters values.
Jotanović Stoja +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Current Issues in Pharmacy and Medical Sciences, 2010 The aim of this study was to estimate a 14-day simultaneous usage of simvastatin and amitriptyline on the some biochemical parameters indicating liver and kidney functions in rats.
Mariola Herbet +2 more
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The effects ofesterified glucomannan on some biochemical parameters during experimental aflatoxicosis in japanese quails [PDF]
Eurasian Journal of Veterinary Sciencesln this study it was aimed to determine protective effects of different doses (1 g/kg and 2 g/kg feed GM) esterified glucomannan (GM) against to experimentally chronic aflatoxicosis (1 mg/kg feed AF) in Japanese quails (Coturnix coturnix japonica).
Banu ATALAY, Zafer DURGUN
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source