Results 71 to 80 of about 240,710 (295)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Noise-induced Input Dependence in a Convective Unstable Dynamical System

, 1998
Unidirectionally coupled dynamical system is studied by focusing on the input (or boundary) dependence. Due to convective instability, noise at an up-flow is spatially amplified to form an oscillation. The response, given by the down-flow dynamics, shows
Fujimoto, Koichi, Kaneko, Kunihiko
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Co-occurrence of resonant activation and noise-enhanced stability in a model of cancer growth in the presence of immune response

, 2006
We investigate a stochastic version of a simple enzymatic reaction which follows the generic Michaelis-Menten kinetics. At sufficiently high concentrations of reacting species, the molecular fluctuations can be approximated as a realization of a Brownian
A. Ochab-Marcinek, Alessandro Fiasconaro, Anna Ochab-Marcinek, Bernardo Spagnolo, C. W. Gardiner, Ewa Gudowska-Nowak, J. M. Fryxell, J. M. Levine, N. S. Goel, P. Zhivkov, R. Lefever, R. N. Mantegna, T. G. Kurtz, V. S. Anishchenko, W. Horsthemke   +14 more
core   +1 more source

Gold nanorods as molecular contrast agents in photoacoustic imaging: the promises and the caveats\ud [PDF]

, 2011
Rod-shaped gold nanoparticles exhibit intense and narrow absorption peaks for light in the far-red and near-infrared wavelength regions, owing to the excitation of longitudinal plasmons.
Leeuwen, Ton G. van, Manohar, Srirang, Ungureanu, Constantin   +2 more
core   +4 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Light Manipulation in Inhomogeneous Liquid Flow and Its Application in Biochemical Sensing

Micromachines, 2018
Light manipulation has always been the fundamental subject in the field of optics since centuries ago. Traditional optical devices are usually designed using glasses and other materials, such as semiconductors and metals.
Yunfeng Zuo, Xiaoqiang Zhu, Yang Shi, Li Liang, Yi Yang   +4 more
doaj   +1 more source

Physics of Transport and Traffic Phenomena in Biology: from molecular motors and cells to organisms

, 2005
Traffic-like collective movements are observed at almost all levels of biological systems. Molecular motor proteins like, for example, kinesin and dynein, which are the vehicles of almost all intra-cellular transport in eukayotic cells, sometimes ...
Aghababaie, Anderson, Anderson, Anderson, Anderson, Anderson, Andreas Schadschneider, Antal, Aridor, Aridor, Arndt, Arndt, Astumian, Bonabeau, Bonabeau, Bonabeau, Bonabeau, Bonabeau, Burd, Burd, Burstedde, Camazine, Chopard, Chopard, Chou, Chowdhury, Chowdhury, Chowdhury, Coffey, Couzin, de Gier, Debashish Chowdhury, Derenyi, Derenyi, Derrida, Derrida, Derrida, Dorigo, Ebneth, Edelstein-Keshet, Evans, Evans, Evans, Evans, Evans, Feynman, Fisher, Frey, Fukui, Gautrais, Gipps, Goldstein, Goldstein, Goldstein, Goldstein, Goldstein, Grimm, Gross, Gueron, Hackney, Harms, Helbing, Helbing, Helbing, Helbing, Helbing, Helbing, Henderson, Hiratsuka, Hirokawa, Howard, Huang, Hughes, Hughes, Hölldobler, Jackson, Janowsky, John, Juhasz, Juhasz, Jülicher, Kafri, Katsuhiro Nishinari, Kirchner, Kirchner, Kirchner, Klein, Klumpp, Klumpp, Klumpp, Klumpp, Klüpfel, Kolomeisky, Krieger, Krug, Krug, Kruse, Ktitarev, Lakatos, Leduc, Lee, Lipowsky, Lipowsky, MacDonald, MacDonald, Mahnke, Mai, Mandelkow, Marchesoni, Marconi, Marro, Mikhailov, Mogilner, Mukherji, Muramatsu, Nagase, Nakayama, Nedlec, Nedlec, Nieuwenhuizen, Nieuwenhuizen, Nishinari, Nishinari, Nitta, O'Loan, O'Loan, Odell, Okada, Okada, Okada, Parmeggiani, Parmeggiani, Popescu, Popkov, Popkov, Popkov, Railsback, Rajewsky, Rajewsky, Ratnieks, Ratnieks, Rauch, Reimann, Risken, Saffarian, Sankararaman, Schadschneider, Schmittmann, Schweitzer, Schütz, Schütz, Shaw, Shaw, Shaw, Smoluchowski, Stamer, Surrey, Theraulaz, Theraulaz, Thompson, Tripathi, Watmough, Weibel, Welte, Whittaker, Wilson, Wolfram, Wolfram, Ziebert   +168 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source