Results 151 to 160 of about 139,343 (219)

The long and winding road: On the endoplasmic reticulum of Plasmodium and implications for pathogenesis. [PDF]

PLoS Pathog
Blank A, Ngwira S, Fierro MA.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The 100 Diatom Genomes Project. [PDF]

PLoS Biol
Mock T, Bilcke G, Flaum E, Fu S, Hoch L, Moog K, Rijsdijk N, Ruck EC, Bishop IW, Duchene C, Gilbertson R, Hopes A, Johns C, Manfellotto F, Roberts WR, Belshaw N, Chandola U, Chaerle P, Chepurnova O, Deleu D, D'hondt S, Di Costanzo F, Dudin O, Flori S, Gaikwad T, Groisillier A, Hall A, Ji P, Lavier-Aydat LJ, Lewis WH, Menicot S, Pinseel E, Pottier E, Sarkozi K, Smerilli A, Strauss J, Thierens S, Toseland A, Touhami Y, Utting R, Van Bel M, van Oosterhout C, Wu Y, Yang F, Allhusen E, Bolton JJ, Bowler C, Brinkhoff T, Poehlein A, Brovarone T, Chen N, Clark G, Clark MD, Copetti D, Cui Z, Deng B, Jian J, John U, Jungblut AD, Kang J, Kristoffersen JB, Lee J, Liu S, Mann DG, Medlin L, Moulton V, Radojicic J, Sato S, Trobajo R, Wolf K, Yamada N, Ye N, Zhang L, Zhuang Y, Dey G, Di Dato V, Helliwell K, Jaubert M, Kroth PG, Montresor M, Romano G, Rynearson TA, Talag J, Valentin KU, Vincent F, Waller RF, Wheeler G, Alverson AJ, Barry K, Boston L, Falciatore A, Ferrante MI, Guo J, Grimwood J, Hayes R, Herdean A, Jenkins J, Kim M, Kooistra WH, Kuo A, Lipzen A, Poulsen N, Schmutz J, Tirichine L, Vandepoele K, Verret F, Vyverman W, Grigoriev IV.   +107 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Optogenetic Evidence for the Intrinsic Phase Separation Propensity of the Sgs1 N-Terminal Region: Implications for Assemblysome Formation. [PDF]

Biomolecules
Gombás BG, Gábor E, Honti V, Németh-Szatmári O, Jankovics F, Villányi Z.   +5 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Remembering stress, shaping resilience: plant adaptation across scales. [PDF]

Essays Biochem
Luna E.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transposable elements in the era of data science EMBO course: a call for open, accessible, and collaborative TE resources. [PDF]

Mob DNA
Paschoal AR, de Goes FR, Makałowski W, Karakülah G, Berrens RV, Lerat E, Vieira C, Ou S, Fiston-Lavier AS, Van Sluys MA, Guyot R.   +10 more
europepmc   +1 more source