Results 221 to 230 of about 352,777 (258)

ABCC11 Earwax Trait and Genotype Are Suitable Tools for Introductory Labs to Learn Genetics and Molecular Techniques. [PDF]

Biochem Mol Biol Educ
Ohta T, Takai R, Yoshida A, Paudel D, Giri S, Kitagawa T, Arakawa T, Kuramitsu Y, Tokutomi T.   +8 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

<i>CFTR</i> gene variant detection in moroccan individuals via nanopore long-read sequencing. [PDF]

Front Genet
El Makhzen N, Nater A, Rougier JS, Bokhobza A, Sanz J, Zweier C, Hämmerli AF, Bruggmann R, Bouguenouch L, Lakhdar Idrissi M, Abriel H.   +10 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies. [PDF]

Am J Hum Genet
Di Donato N, NMA Consortium, Thom A, Rump A, Greve JN, Cadiñanos J, Calabrò RS, Cathey S, Chung B, Cope H, Costales M, Cuvertino S, Dinkel P, Erripi K, Fry AE, Garavelli L, Hoffjan S, Janzarik WG, Kreimer I, Mancini G, Marin-Reina P, Meinhardt A, Niehaus I, Pilz D, Ricca I, Simarro FS, Schrock E, Marquardt A, Taft MH, Tezcan K, Thunström S, Verhagen J, Verloes A, Wollnik B, Krawitz P, Hsieh TC, Seifert M, Heide M, Lawrence CB, Roberts NA, Manstein DJ, Woolf AS, Banka S.   +42 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Correction: A revision of the genus <i>Beesia</i> (Ranunculaceae) as informed through integrative taxonomy, with description of a new species from Sichuan (China). [PDF]

Front Plant Sci
Erst AS, Mitrenina EY, Krivenko DA, Erst TV, Cheldysheva YV, Gorbenko IV, Borosova R, Lian L, Ling YY, Peng HW, Zhang J, Baasanmunkh S, Choi HJ, Tatanov IV, Kuznetsov AA, Sharples MT, Xiang KL.   +16 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Editorial: In honor of Dr. Bruce Ames: innovations in mutagenesis and DNA repair. [PDF]

Front Mol Biosci
Giulivi C, Traber MG.
europepmc   +1 more source

Subject benchmark statement: biomedical science : draft for consultation June 2007 [PDF]

core