Results 141 to 150 of about 538,242 (306)

Keeping the Vimentin Network Under Control: Cell-matrix Adhesion-associated Plectin 1f Affects Cell Shape and Polarity of Fibroblasts

, 2010
Monitoring Editor: M. Bishr Omary Focal adhesions (FAs) located at the ends of actin/myosin-containing contractile stress fibers form tight connections between fibroblasts and their underlying extracellular matrix.
Lilli Winter, Gerald Burgstaller, Wiche, Gerhard (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Gerhard Wiche, Martin Gregor, Winter, Lilli (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Gregor, Martin (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Burgstaller, Gerald (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna)   +7 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Erythropoietic Defect Associated with Reduced Cell Proliferation in Mice Lacking the 26S Proteasome Shuttling Factor Rad23b

, 2013
Rad23a and Rad23b proteins are linked to nucleotide excision DNA repair (NER) via association with the DNA damage recognition protein xeroderma pigmentosum group C (XPC) are and known to be implicated in protein turnover by the 26S proteasome.
Clapes, T. (Thomas), Toussaint, W., Maas, A., Kulu, Divine, Kulu, D.I. (Divine), Mitchell, James R., Mitchell, JR (James), van Alphen, F.P., Clapes, T., Gutierrez, L, Marteijn, J.A. (Jurgen), Toussaint, W. (Wendy), Bergink, Steven, Mul, E.P. (Eric), Clapes, Thomas, Marteijn, Jurgen, Demmers, J.A., Bergink, S (Steven), van Alphen, FP, Bergink, S., Gent, T. (Teus) van, Maas, Alex, Kulu, Divine I., Mul, E.P., van der Linden, Reinier, Alphen, F.P. (Floris) van, Mul, EP, De Cuyper, Iris M., Gutierrez, L., Vermeulen, Wim, Mul, Eric P., Vermeulen, W., Linden, Reinier, Toussaint, Wendy, Robin, Catherine, Theil, A.F. (Arjan), Maas, A. (Alex), De Cuyper, I.M., Marteijn, J.A., Cuyper, I.M. (Iris) de, Robin, C., Gutiérrez, L. (Laura), Kulu, D.I., Philipsen, S., Theil, Arjan, Theil, A.F., Mitchell, J.R., Gutierrez, Laura, Demmers, Jeroen, van Alphen, Floris P., Philipsen, J.N.J. (Sjaak), Philipsen, Sjaak, Linden, R. (Reinier) van der, De Cuyper, IM, van der Linden, R., Toussaint, WM, Theil, Arjan F., Marteijn, Jurgen A., Gent, T, Mitchell, J.R. (James), Demmers, Jeroen A., van Gent, T., Bergink, S. (Steven), van Gent, Teus, Vermeulen, W. (Wim), Demmers, J.A.A. (Jeroen), Robin, C. (Catherine)   +66 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

On the emergence and evolution of artificial cell signaling networks [PDF]

, 2007
This PhD project is concerned with the evolution of Cell Signaling Networks (CSNs) in silico. CSNs are complex biochemical networks responsible for the coordination of cellular activities.
Decraene, James
core   +1 more source

The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR

Scientific Reports
The protein tyrosine phosphatases (PTPs) TCPTP, PTPN22, and SHP1 are critical regulators of the activating phosphotyrosine (pY) site on the initiating T cell kinase, LckY394.
Aurora Callahan, Aisharja Mojumdar, Mengzhou Hu, Amber Wang, Alijah A. Griffith, Nicholas Huang, Xien Yu Chua, Nick Mroz, Ryan Z. Puterbaugh, Shanelle P. Reilly, Arthur Salomon   +10 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source