Results 301 to 310 of about 339,187 (318)

Enhanced PDMS Functionalization for Organ‐on‐a‐Chip Platforms Using Ozone and Sulfo‐SANPAH: A Simple Approach for Biomimetic Long‐Term Cell Cultures

open access: yesAdvanced Healthcare Materials, EarlyView.
The use of organ‐on‐a‐chip (OOC) microfluidic platforms is expanding in biomedical research. While this emerging technology is becoming increasingly accessible, the stability of long‐term functional cultures remains a critical challenge to address. This study presents a straightforward, one‐step method for the functionalization of polydimethylsiloxane ...
Mitzi Pérez‐Calixto   +7 more
wiley   +1 more source

TPMS‐Gyroid Scaffold‐Mediated Up‐Regulation of ITGB1 for Enhanced Cell Adhesion and Immune‐Modulatory Osteogenesis

open access: yesAdvanced Healthcare Materials, EarlyView.
A) SLM generates biomimetic bone scaffolds with consistent porosity but varying TPMS‐Gyroid unit cell designs (TG15, TG20, TG25, TG30). B) By enhancing the expression of ITGB1, TPMS‐Gyroid scaffolds can facilitate osteogenic differentiation in BMSCs and promote M2 polarization in macrophages.
Jing Wang   +9 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq   +4 more
wiley   +1 more source

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

open access: yesAdvanced Healthcare Materials, EarlyView.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold   +2 more
wiley   +1 more source

New Direction in Antimicrobial Delivery System: Preparation and Applications of Hydrogel Microspheres. [PDF]

open access: yesPharmaceutics
Li J   +8 more
europepmc   +1 more source

HGF/c‐Met Axis‐Targeted Nanotherapy via GSH‐Responsive Polymer Platforms Suppresses Uveal Melanoma Metastasis

open access: yesAdvanced Healthcare Materials, EarlyView.
To suppress uveal melanoma metastasis (UM), the GSH‐responsive polymer named NP@Oxa/Criz has been successfully prepared. NP@Oxa/Criz selectively accumulates in UM tumors, targeting HGF/c‐Met Axis to undermine the stemness and metastasis of UM while triggering immunogenic cell death through DAMPs release to boost anti‐tumor immunity.
Hui Tao   +8 more
wiley   +1 more source

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