Results 101 to 110 of about 446,044 (333)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Bioengineering 3D Pancreatic Cancer Models with Fibrotic Stroma for In Vitro Cancer Modeling

Micromachines
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to late diagnosis, high malignancy, and profound resistance to therapy. Traditional two-dimensional (2D) cell cultures fail to recapitulate the complex tumor microenvironment (TME ...
Xingrun Lan, Keke Chen, Xiaoyun Wei
doaj   +1 more source

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion [PDF]

, 2018
Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ...
Bouzos, Evangelia, Chau, Huong, Farias, Chantell, Hemingway, Cecilia, Lyman, Roman, Mahacek, Anne, Mobed-Miremadi, Maryam   +6 more
core   +3 more sources

Bioengineering: Solar upgrade [PDF]

Nature, 2017
Plant scientists are redesigning photosynthesis to improve crop yields and feed a growing population.
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Considerations and implications of current in vitro model systems to study optic nerve head cellular mechanobiology

Frontiers in Cell and Developmental Biology
The optic nerve head (ONH) is a primary site of biomechanical strain within the eye. Here, tensile, compressive and shear forces can impact both physiologic function and pathologic dysfunction of the tissue.
Ana N. Strat, Ana N. Strat, Preethi S. Ganapathy, Preethi S. Ganapathy, Preethi S. Ganapathy   +4 more
doaj   +1 more source

Some questions of space bioengineering [PDF]

Zero-gravity offers selective effect on growth and metabolic activity unicellular organisms as well as unique opportunities in purification of organic compounds.
Nyiri, L. K.
core   +1 more source

Bioengineered polyester nanoparticles for the synergistic treatment of androgenic alopecia via the suppression of 5α-reductase and knockdown of androgen receptor

, 2022
Xiangru Chen, Peiyu Yan, Wenqiang Zhang, Feng He, Rihua Jiang, Yulin Li, Jing Sun, Jinlan Jiang   +7 more
openalex   +1 more source

Immobilization of Bioengineered Portal Protein Within a Solid-State Nanopore for Molecular Sensing [PDF]

, 2020
Mehrnaz Mojtabavi, Sandra J. Greive, Alfred A. Antson, Meni Wanunu   +3 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source