Results 81 to 90 of about 305,111 (300)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bioengineering 3D Pancreatic Cancer Models with Fibrotic Stroma for In Vitro Cancer Modeling

Micromachines
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to late diagnosis, high malignancy, and profound resistance to therapy. Traditional two-dimensional (2D) cell cultures fail to recapitulate the complex tumor microenvironment (TME ...
Xingrun Lan, Keke Chen, Xiaoyun Wei
doaj   +1 more source

Are short implants in the mandible safe? [PDF]

RGO: Revista Gaúcha de Odontologia, 2009
Objective: To analyze the importance of bioengineering and the improvement in surgical techniques demonstrated by the rates attained of the prevalence of successful placement of dental implants in the posterior region of the mandible, in D3 bone quality ...
Sergio Henrique Gonçalves Motta, Marcelo Barbosa Barros, Flávia Rabello de Mattos, Andrea Leonardo da Silva, Ana Roseli de Queiroz Gonçalves   +4 more
doaj  

Biotechnology and Bioengineering [PDF]

, 2019
Biotechnology and Bioengineering presents the most up-to-date research on biobased technologies. It is designed to help scientists and researchers deepen their knowledge in this critical knowledge field.

core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Considerations and implications of current in vitro model systems to study optic nerve head cellular mechanobiology

Frontiers in Cell and Developmental Biology
The optic nerve head (ONH) is a primary site of biomechanical strain within the eye. Here, tensile, compressive and shear forces can impact both physiologic function and pathologic dysfunction of the tissue.
Ana N. Strat, Ana N. Strat, Preethi S. Ganapathy, Preethi S. Ganapathy, Preethi S. Ganapathy   +4 more
doaj   +1 more source

Bioengineering of Intestinal Grafts

Gastroenterology Clinics of North America
Intestinal failure manifests as an impaired capacity of the intestine to sufficiently absorb vital nutrients and electrolytes essential for growth and well-being in pediatric and adult populations. Although parenteral nutrition remains the mainstay therapeutic approach, the pursuit of a definitive and curative strategy, such as regenerative medicine ...
Herath, Madushani, Speer, Allison L.
openaire   +2 more sources

'In the world, but not of it': Exploring the impacts of hearing loss stigma

, 2011
This seminar was delivered on 21st September 2011 by Dr Kenneth Southall from the Institut de recherche Élisabeth-Bruyère, affiliated with University of Ottawa, Canada.
Brunel Institute for Bioengineering Seminar Series, Southall, K   +1 more
core  

Bioengineering strategies for human neuromuscular tissue modeling

, 2022
openStrategie bioingegneristiche per la modellazione del tessuto neuromuscolare umano. In particolare avvalendosi dell'utilizzo di un diaframma di topo decellularizzato e in seguito ripopolato.
BARBATO, GILDA
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source