Results 71 to 80 of about 449,656 (351)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Preclinical approaches in regenerative medicine for treating end-stage renal disease: a scoping review

Frontiers in Endocrinology
A scoping review was conducted to systematically assess the current evidence and emerging applications of regenerative medicine in the treatment of End Stage Renal Disease (ERSD), aiming to map existing knowledge and identify key research gaps.
Andrea Vigezzi, Paola Brani, Daniela Dalla Gasperina, Lorenzo Azzi, Cristina Giaroni, Davide Inversini, Giuseppe Pettinato, Matthew Massaad, Giulio Carcano, Giuseppe Ietto, Andreina Baj   +10 more
doaj   +1 more source

Bioengineering of Crops Could Help Feed the World: Crop Increases of 10-25 Percent Possible [PDF]

, 1997
News release on a CGIAR-World Bank report 'Bioengineering of Crops' describing the potential of agricultural bioengineering to increase crop yields by 10 to 25 percent over the next 30 ...
CGIAR Secretariat
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Bioengineering approaches to trained immunity: Physiologic targets and therapeutic strategies

eLife
Trained immunity presents a unique target for modulating the immune response against infectious and non-infectious threats to human health. To address the unmet need for training-targeted therapies, we explore bioengineering methods to answer research ...
Hannah Riley Knight, Marie Kim, Nisha Kannan, Hannah Taylor, Hailey Main, Emily Azcue, Aaron Esser-Kahn   +6 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Electromyography-Triggered Constraint-Induced Movement Cycling Therapy for Enhancing Motor Function in Chronic Stroke Patients: A Randomized Controlled Trial

Bioengineering
This single-blind randomized controlled trial investigated the effectiveness of surface electromyography (sEMG)-triggered constraint-induced movement cycling therapy (CIMCT) in improving balance, lower extremity strength, and activities of daily living ...
Jaemyoung Park, Kyeongjin Lee, Junghyun Kim, Changho Song   +3 more
doaj   +1 more source

Biomass-supported catalysts on Desulfovibrio desulfuricans and Rhodobacter sphaeroides [PDF]

, 2008
A Rhodobacter sphaeroides-supported dried, ground palladium catalyst (‘‘Rs-Pd(0)’’) was compared with a Desulfovibrio desulfuricans-supported catalyst (‘‘Dd-Pd(0)’’)and with unsupported palladium metal particles made by reduction under H2 (‘‘Chem-Pd(0)’’)
Baxter-Plant, VS, Deplanche, K, Macaskie, LE, Redwood, MD   +3 more
core  

Muscle Synergies Facilitate Computational Prediction of Subject-Specific Walking Motions. [PDF]

, 2016
Researchers have explored a variety of neurorehabilitation approaches to restore normal walking function following a stroke. However, there is currently no objective means for prescribing and implementing treatments that are likely to maximize recovery ...
Andrew J Meyer, Anil V Rao, Benjamin J Fregly, Carolynn Patten, Carolynn Patten, Ilan Eskinazi, Jennifer N Jackson   +6 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source