Results 51 to 60 of about 334,029 (292)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Bioengineering approaches to trained immunity: Physiologic targets and therapeutic strategies

eLife
Trained immunity presents a unique target for modulating the immune response against infectious and non-infectious threats to human health. To address the unmet need for training-targeted therapies, we explore bioengineering methods to answer research ...
Hannah Riley Knight, Marie Kim, Nisha Kannan, Hannah Taylor, Hailey Main, Emily Azcue, Aaron Esser-Kahn   +6 more
doaj   +1 more source

Liver bioengineering using decellularized whole-liver scaffolds [PDF]

, 2018
Currently, due to the progress made in the field of regenerative medicine, whole-organ bioengineering is becoming a valid alternative to cope with the shortages of organs for transplantation.
Sainz-Arnal, P., Baptista, P.M., Pla-Palacín, I., Morini, S., Almeida, M.   +4 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Electromyography-Triggered Constraint-Induced Movement Cycling Therapy for Enhancing Motor Function in Chronic Stroke Patients: A Randomized Controlled Trial

Bioengineering
This single-blind randomized controlled trial investigated the effectiveness of surface electromyography (sEMG)-triggered constraint-induced movement cycling therapy (CIMCT) in improving balance, lower extremity strength, and activities of daily living ...
Jaemyoung Park, Kyeongjin Lee, Junghyun Kim, Changho Song   +3 more
doaj   +1 more source

Test Tube Tooth: The Next Big Thing [PDF]

Journal of Clinical and Diagnostic Research, 2016
Unlike some vertebrates and fishes, humans do not have the capacity for tooth regeneration after the loss of permanent teeth. Although artificial replacement with removable dentures, fixed prosthesis and implants is possible through advances in the ...
Preeti Yadav, Mohammed Tahir, Harsh Yadav, Rakshit Sureka, Aarti Garg   +4 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Finite Element Analysis of the Bearing Component of Total Ankle Replacement Implants during the Stance Phase of the Gait Cycle

BioMedInformatics
Total ankle arthroplasty (TAA) is a motion-preserving treatment for end-stage ankle arthritis. An effective tool for analyzing these implants’ mechanical performance and longevity in silico is finite element analysis (FEA).
Timothy S. Jain, Mohammad Noori, Joseph J. Rencis, Amanda Anderson, Naudereh Noori, Scott Hazelwood   +5 more
doaj   +1 more source

Bioengineering horizon scan 2020

eLife, 2020
Horizon scanning is intended to identify the opportunities and threats associated with technological, regulatory and social change. In 2017 some of the present authors conducted a horizon scan for bioengineering (Wintle et al., 2017).
Luke Kemp, Laura Adam, Christian R Boehm, Rainer Breitling, Rocco Casagrande, Malcolm Dando, Appolinaire Djikeng, Nicholas G Evans, Richard Hammond, Kelly Hills, Lauren A Holt, Todd Kuiken, Alemka Markotić, Piers Millett, Johnathan A Napier, Cassidy Nelson, Seán S ÓhÉigeartaigh, Anne Osbourn, Megan J Palmer, Nicola J Patron, Edward Perello, Wibool Piyawattanametha, Vanessa Restrepo-Schild, Clarissa Rios-Rojas, Catherine Rhodes, Anna Roessing, Deborah Scott, Philip Shapira, Christopher Simuntala, Robert DJ Smith, Lalitha S Sundaram, Eriko Takano, Gwyn Uttmark, Bonnie C Wintle, Nadia B Zahra, William J Sutherland   +35 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source