Results 31 to 40 of about 334,029 (292)
Bioengineering Liver Organoids for Diseases Modelling and Transplantation
, 2022 Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications.
Shangsi Chen +17 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A swimming robot actuated by cultured skeletal muscle tissue
Nihon Kikai Gakkai ronbunshu, 2020 Biohybrid robots composed of synthetic skeletons and living components have recently gained interests as a solution to engineering biological dynamic systems.
Kazuma MATSUSHITA +2 more
doaj +1 more source
Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues
Frontiers in Surgery, 2021 Collagens represent a major group of structural proteins expressed in different tissues and display distinct and variable properties. Whilst collagens are non-transparent in the skin, they confer transparency in the cornea and crystalline lens of the eye.
Yihui Song +12 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
MEDICINE AND ENGINEERING – CONNECTION BIOLOGY, TECHNOLOGY AND INFORMATICS [PDF]
Acta Tecnología, 2017 Biomedical engineering is a broad field that covers a wide range of medical disciplines. Increasingly, nature is linked to engineering and technology. There is a breakthrough in chemical engineering and nanotechnology.
Marianna Trebuňová +2 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2022 Synthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved and designed material and software.
Michael Levin, Michael Levin
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Cardiovascular diseases represent the major cause of morbidity and mortality worldwide. Multiple studies have been conducted so far in order to develop treatments able to prevent the progression of these pathologies.
Marta Mazzola +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source