Results 31 to 40 of about 305,111 (300)
General method to stabilize mesophilic proteins in hyperthermal water
iScience, 2021 Summary: The stability of protein structures and biological functions at normal temperature is closely linked with the universal aqueous environment of organisms.
Xiaoqian Xin +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease
EXCLI Journal : Experimental and Clinical Sciences, 2023 Non-alcoholic fatty liver disease (NAFLD) has become the world’s most common chronic liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development studies have faced many limitations, and there is no food and drug ...
Negar Aasadollahei +5 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Bioengineered MSC-derived exosomes in skin wound repair and regeneration
Frontiers in Cell and Developmental Biology, 2023 Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy.
Hanxing Zhao +21 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A swimming robot actuated by cultured skeletal muscle tissue
Nihon Kikai Gakkai ronbunshu, 2020 Biohybrid robots composed of synthetic skeletons and living components have recently gained interests as a solution to engineering biological dynamic systems.
Kazuma MATSUSHITA +2 more
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Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues
Frontiers in Surgery, 2021 Collagens represent a major group of structural proteins expressed in different tissues and display distinct and variable properties. Whilst collagens are non-transparent in the skin, they confer transparency in the cornea and crystalline lens of the eye.
Yihui Song +12 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Abstracts of the 1st International Online Conference on Bioengineering
Engineering ProceedingsThe 1st International Online Conference on Bioengineering (IOCBE 2024) was held online from 16 to 18 October 2024. With a theme of Bioengineering in a Generative AI World, the conference featured presentations from distinguished scholars at the nexus of ...
Anthony Guiseppi-Elie, Rossana Madrid
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