Results 131 to 140 of about 446,044 (333)

Bioengineering Microgels and Hydrogel Microparticles for Sensing Biomolecular Targets [PDF]

, 2017
Edmondo Battista, Filippo Causa, Paolo A. Netti   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Executive summary: Workshop on preterm birth, January 28–29, 2025, co‐sponsored by the American College of Obstetricians and Gynecologists and the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Pregnancy
The Society for Maternal‐Fetal Medicine collaborated with the American College of Obstetricians and Gynecologists and the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health to co‐sponsor ...
Society for Maternal‐Fetal Medicine (SMFM), Rupsa Boelig, Andrea Edlow, Tracy Manuck, Eva Pajkrt, Ina A. Stelzer, Sarahn Wheeler, Cynthia Gyamfi‐Bannerman   +7 more
doaj   +1 more source

Cavitation in Biological and Bioengineering Contexts [PDF]

, 2003
There are an increasing number of biological and bioengineering contexts in which cavitation is either utilized to create some desired effect or occurs as a byproduct of some other process.
Brennen, Christopher E.
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Looking into the Eye with REAP [PDF]

, 2019
Keratoprosthesis is an artificial cornea that is surgically implanted in the eye to replace damaged cornea, correcting corneal blindness. Keratoprosthesis offers a unique solution that eliminates the possible rejection of donor cornea, a common problem ...
Boudreau, Ryann
core   +1 more source

Formative Assessment and Professional Training: Reflections from a Mathematics course in Bioengineering [PDF]

, 2016
Carolina Carrere, Solange Milesi, I Lapyckyj, Enrico Ravera, Leandro Escher, Alberto Miyara, Gema Isabel Arauz Pita, María Magdalena Añino   +7 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source